Mouse Anti-TREM1 Monoclonal Antibody

• Cat.No.: DMABT-H18610
• Product Overview: Mouse Anti-TREM1 Monoclonal Antibody

Specification

• Species: Human
• Source: Mouse
• Tag: APC
• Antigen Description: TREM-1 is a 30 kD glycoprotein also known as triggering receptor expressed on myeloid cells 1, and triggering receptor expressed on monocytes 1. It is a Type I membrane protein that contains an immunoglobulin-like V-type domain. Alternatively spliced protein variant may be secreted. TREM-1 is highly expressed on peripheral blood myeloid cells (particularly mature monocytes and granulocytes); TREM-1 expression can be further upregulated by bacteria, fungi and lipopolysaccharide. TREM-1 has been shown to interact with the adaptor protein DAP12 to stimulate neutrophil and monocyte-mediated inflammatory responses through the triggering and release of pro-inflammatory cytokines and chemokines. TREM-1 is thought to amplify inflammatory responses to fungal and bacterial infections and potentiate septic shock.
• Target: TREM1
• Immunogen: Recombinant human TREM-1
• Isotype: IgG1, kappa
• species: Human
• Conjugation: APC
• Applications: Flow Cyt
• Preparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions. The solution is free of unconjugated APC and unconjugated antibody.
• Usage recommendation: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis.Test size products are transitioning from 20 μl to 5 μl per test. Please check your vial or your CoA to find the suggested use of this reagent per million cells in 100 μl staining volume or per 100 μl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. Read more at www.biolegend.com/testsize regarding the test size change.
• Storage: The antibody solution should be stored undiluted at 4 °C and protected from prolonged exposure to light.Do not freeze.
• Size: 100 tests

Gene Information

• Gene Name: TREM1 triggering receptor expressed on myeloid cells2[ Homo sapiens ]
• Official Symbol: TREM1
• Synonyms: TREM1; triggering receptor expressed on myeloid cells 1; CD354; TREM 1; triggering-receptor TREM1; triggering receptor expressed on monocytes 1; TREM-1
• Gene ID: 54210
• mRNA Refseq: NM_001242589
• Protein Refseq: NP_001229518
• MIM: 605085
• UniProt ID: Q9NP99
• Chromosome Location: 6p21.1
• Pathway: Cell surface interactions at the vascular wall, organism-specific biosystem; Hemostasis, organism-specific biosystem
• Function: receptor activity