Human Elastase

• Cat.No.: ELANE-1653H
• Product Overview: Human ELANE having a molecular mass of 29.5kDa was purified from Human Neutrophil.

Specification

• Species: Human
• Tag: Non
• Description: ELANE, like trypsin and chymotrypsin, is a serine protease that also hydrolyses amides and esters. It is produced in the pancreas as an inactive zymogen, proelastase, and activated in the duodenum by trypsin. ELANE is distinctive in that it acts upon elastin.This enzyme degrades elastin, collagen, and proteoglycan and has been implicated in the development of pulmonary emphesema and rheumatoid arthritis.
• Biological Activity: 20-22 units per mg protein. One unit is defined as the amount of enzyme that hydrolyzes one micromole of Meo-Suc-Ala-Pro-Val-pNA per minute at 25°C in 100 mMTris-HCl, pH 7.5, with 500 mMNaCl.
• Molecular Weight: 29.5 kDa
• Form: Salt- free lyophilized solid
• Appearance: Lyophilized protein
• Reconstitution: Deionized water
• Purity: ≥95% by SDS-PAGE
• Storage: -20°C
• Pathways: C-MYB transcription factor network; Systemic lupus erythematosus; amb2 Integrin signaling

Gene Information

• Gene Name: ELANE elastase, neutrophil expressed [ Homo sapiens ]
• Official Symbol: ELANE
• Synonyms: ELANE; elastase, neutrophil expressed; GE; NE; HLE; HNE; ELA2; SCN1; PMN-E ; neutrophil elastase ; elastase-2; medullasin; PMN elastase; leukocyte elastase; elastase 2, neutrophil; human leukocyte elastase; polymorphonuclearelastase; bone marrow serine protease; granulocyte-derived elastase; elastase, neutrophil expressed; Bone marrow serine protease; Human leukocyte elastase; PMN elastase; granulocyte-derived elastase; EC 3.4.21.37; Elastase-2; Medullasin; EC 3.4.21
• Gene ID: 1991
• mRNA Refseq: NM_001972
• Protein Refseq: NP_001963
• MIM: 130130
• UniProt ID: P08246
• Chromosome Location: 19p13.3
• Function: bacterial cell surface binding; cytokine binding; endopeptidase activity; heparin binding; peptidase activity; protein binding; serine-type endopeptidase activity