Recombinant Human IL7, His-tagged

• Cat.No.: IL7-65H
• Product Overview: IL-7 Human Recombinant produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 152 amino acids fragment (26-177) and having a total molecular mass of 21.97 kDa with an amino-terminal hexahistidine tag. The IL-7 His-Tag protein is purified by proprietary chromatographic techniques.

Specification

• Description: The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed.
• Source: E.Coli
• Species: Human
• Tag: His
• Form: Sterile Filtered clear solution. Interleukin -7 His is supplied in 1x PBS and 50% glycerol.
• Molecular Mass: 21.97 kDa
• Purity: Greater than 95.0% as determined by RP-HPLC and SDS-PAGE.
• Stability: Store at 4ºC if entire vial will be used within 2-4 weeks. Store, frozen at -20ºC for longer periods of time. Please avoid freeze thaw cycles.
• Protein length: 26-177 a.a.

Gene Information

• Gene Name: IL7 interleukin 7 [ Homo sapiens (human) ]
• Official Symbol: IL7
• Synonyms: IL7; IL-7; interleukin 7; interleukin-7
• Gene ID: 3574
• mRNA Refseq: NM_000880
• Protein Refseq: NP_000871
• MIM: 146660
• UniProt ID: P13232
• Chromosome Location: 8q12-q13
• Pathway: Cytokine Signaling in Immune system; Hematopoietic cell lineage; Interleukin-7 signaling
• Function: cytokine activity; growth factor activity; interleukin-7 receptor binding