Human CXCL11, Biotin-tagged

• Cat.No.: CXCL11-106H
• Product Overview: It is a synthetic Protein with Biotin tag.

Specification

• Species: Human
• Tag: Non
• Description: Interferon-inducible T cell a chemoattractant (ITAC), which is also known as SCYB9B, -R1 or H174, is a non-ELR CXC chemokine. ITAC"s cDNA encodes a 94 amino acid precursor with a 21 amino acid putative signal sequence which is cleaved to form the mature 73 amino acid protein. ITAC shares 36% and 37% sequence homology with IP-10 and MIG, respectively. ITAC is expressed at low levels in normal tissues including the thymus, spleen and pancreas. The expression of ITAC mRNA is radically up regulated in interferon- and IL-1 stimulated astrocytes. Moderate increases in expression are also observed in stimulated monocytes. ITAC possesses potent chemoattractant activity for IL-2 activated T-cells and transfected cell lines expressing CXCR3 receptors, but not freshly isolated T-cells, neutrophils or monocytes. The gene which encodes ITAC has been mapped to chromosome 4.
• Form: Lyophilized
• AA Sequence: FPMFKRGRCL CIGPGVKAVK VADIEKASIM YPSNNCDKIE VIITLKENKG QRCLNPKSKQ ARLIIKKVER KNF (Biotin conjugated to C-terminus)
• Applications: Activity Assay
• Storage: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
• Reconstitution: Recommended reconstitution in sterile phosphate buffered saline which contains at least 0.1% human or bovine serum albumin to prepare a stocksolution of no less than 20 μg/ml and vortex thoroughly.

Gene Information

• Gene Name: CXCL11 chemokine (C-X-C motif) ligand 11 [ Homo sapiens ]
• Official Symbol: CXCL11
• Synonyms: CXCL11; chemokine (C-X-C motif) ligand 11; SCYB9B, SCYB11, small inducible cytokine subfamily B (Cys X Cys), member 11; C-X-C motif chemokine 11; b R1; H174; I TAC; IP 9; beta-R1; small inducible cytokine B11; small-inducible cytokine B11; interferon gamma-inducible protein 9; interferon-inducible T-cell alpha chemoattractant; small inducible cytokine subfamily B (Cys-X-Cys), member 11; small inducible cytokine subfamily B (Cys-X-Cys), member 9B; IP9; IP-9; b-R1; I-TAC; SCYB11; SCYB9B; MGC102770
• Gene ID: 6373
• mRNA Refseq: NM_005409
• Protein Refseq: NP_005400
• MIM: 604852
• UniProt ID: O14625
• Chromosome Location: 4q21
• Pathway: CXCR3-mediated signaling events, organism-specific biosystem; Chemokine receptors bind chemokines, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem
• Function: chemokine activity