Active Recombinant Rat Vegfa

• Cat.No.: Vegfa-9928R
• Product Overview: Recombinant Rat VEGF was expressed in CHO Cells.

Specification

• Species: Rat
• Source: CHO
• Tag: Non
• Description: Vascular Endothelial Growth Factor (VEGF) is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability. Expressed in vascularized tissues, Vascular Endothelial Growth Factor (VEGF) plays a prominent role in normal and pathological angiogenesis. Substantial evidence implicates Vascular Endothelial Growth Factor (VEGF) in the induction of tumor metastasis and intra-ocular neovascular syndromes. Vascular Endothelial Growth Factor (VEGF) signals through the three receptors; fms-like tyrosine kinase (flt-1), KDR gene product (the murine homolog of KDR is the flk-1 gene product) and the flt4 gene product.
• Form: Lyophilized after extensive dialysis against PBS.
• Bio-activity: ED50< 4="" ng/ml,="" measured="" in="" a="" cell="" proliferation="" assay="" using="" huvec="" cells,="" corresponding="" to="" a="" specific="" activity="" of="">2.5 x 105 units/mg
• Molecular Mass: 35-48 kDa, observed by non-reducing SDS-PAGE.
• AA Sequence: Ala27-Arg190.
• Endotoxin: < 0.2="" eu/μg,="" determined="" by="" lal="">
• Purity: >95% as analyzed by SDS-PAGE and HPLC.
• Storage: Lyophilized recombinant protein remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rrVEGF165 should be stable up to 1 week at 4°C or up to 2 months at -20°C.
• Reconstitution: Reconstituted in ddH2O or PBS at 100 μg/ml.

Gene Information

• Gene Name: Vegfa vascular endothelial growth factor A [ Rattus norvegicus (Norway rat) ]
• Official Symbol: VEGF
• Synonyms: Vegfa; VPF; Vegf; VEGF-A; VEGF164; vascular endothelial growth factor A; vascular permeability factor
• Gene ID: 83785
• UniProt ID: P16612
• Chromosome Location: 9q12
• Pathway: Bladder cancer, organism-specific biosystem; Cellular response to hypoxia, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem