Active Recombinant Rat Protein Geranylgeranyltransferase Type I, Beta Subunit

• Cat.No.: Pggt1b-324R

Specification

• Cat. No.: Pggt1b-324R
• Description: GGTase-I (Geranylgeranyltransferase-I) catalyzes the transfer of the farnesyl and geranylgeranyl groups from farnesyl and geranylgeranyl-diphosphate to proteins ontaining a C-terminal CaaX motif, where 'C' is a conserved cysteine that is the site of farnesyl modification, 'a' is usually an aliphatic amino acid, and 'X' is leucine or phenylalanine. Farnesyltransferase (FT) and GGTase-I are closely related, sharing a common subunit and 30% identity in their β subunits.
• Source: E. coli.
• Form: Liquid. Supplied in 25 mM HEPES, pH 7.2, 25 mM NaCl and 5 mM DTT.
• Purity: > 90% by SDS-PAGE.
• Activity: 1 pmol of GGTase-I will transfer 5 pmol of Farnesyl to RhoA in 15 min at 37°C.
• Usage: For in vitro use only.
• Storage: Quality guaranteed for 12 months store at - 80°C. Avoid freeze / thaw cycles.
• Tag: Non

Gene Information

• Gene Name: Pggt1b protein geranylgeranyltransferase type I, beta subunit [ Rattus norvegicus ]
• Synonyms: Pggt1b; protein geranylgeranyltransferase type I, beta subunit; geranylgeranyltransferase type 1 beta; geranylgeranyltransferase type I (GGTase-I)
• Gene ID: 81746
• mRNA Refseq: NM_031082
• Protein Refseq: NP_112344
• UniProt ID: P53610
• Chromosome Location: q11
• Function: CAAX-protein geranylgeranyltransferase activity; drug binding; isoprenoid binding; metal ion binding; peptide binding; prenyltransferase activity; protein binding; transferase activity; zinc ion binding