Active Recombinant Mouse Pdcd1lg2, Fc-tagged, Biotinylated

• Cat.No.: Pdcd1lg2-722M
• Product Overview: The recombinant mouse PD-L2-Fc fusion is expressed as a 438 amino acid protein consisting of Leu20 - Thr220 region of mouse PD-L2 (UniProt accession #Q9WUL5) and a C-terminal Fc from human IgG1, which exists as a dimer under non-reducing conditions.

Specification

• Species: Mouse
• Source: Human Cells
• Tag: Fc
• Protein Length: 20-220 a.a.
• Form: Supplied at 0.5 mg/ml in sterile PBS pH7.4 (carrier & preservative free). The purified recombinant protein was labeled with Biotin (3-5 Biotin per molecule).
• Bio-activity: Binds to its receptor PD-1 in a functional ELISA. Blocks the ligand PD-L1"s and PD-L2"s binding to its receptor and mediated signaling activity. Shows cross-species binding to human PD-1.
• Molecular Mass: Calculated molecular mass 49.2 kDa; estimated by SDS-PAGE under reducing condition ~60 kDa (probably due to glycosylation)
• Endotoxin: <0.1 eu="" per="" 1="" μg="" of="" purified="" recombinant="" protein="" determined="" by="" the="" lal="">
• Purity: >95% judged by SDS-PAGE under reducing condition
• Storage: The product is shipped at 4°C. Upon receipt, centrifuge the product briefly before opening the vial. It is recommended to store small aliquots at the temperature below –20°C for long-term storage and the product is stable for 3 months. The undiluted protein can be stored at 4°C for no more than 2 weeks. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: Pdcd1lg2 programmed cell death 1 ligand 2 [ Mus musculus ]
• Official Symbol: Pdcd1lg2
• Synonyms: PDCD1LG2; programmed cell death 1 ligand 2; PD-1 ligand 2; PDCD1 ligand 2; butyrophilin B7-DC; butyrophilin-like protein; programmed death ligand 2; Btdc; B7-DC; PD-L2; F730015O22Rik; MGC124039; MGC124040
• Gene ID: 58205
• mRNA Refseq: NM_021396
• Protein Refseq: NP_067371
• Pathway: Adaptive Immune System, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Costimulation by the CD28 family, organism-specific biosystem; Immune System, organism-specific biosystem; PD-1 signaling, organism-specific biosystem
• Function: protein binding; receptor activity