Recombinant Programmed Cell Death 1 Ligand 2, GST-tagged

• Cat.No.: PDCD1LG2-4491H
• Product Overview: PDCD1LG2 Human Recombinant produced in E.Coli is a single, non-glycosylated, Polypeptide chain fused to a GST tag containing 274 amino acids (1-274) and having a total molecular mass of 56kDa. PDCD1LG2 is purified by proprietary chromatographic techniques.

Specification

• Species: Human
• Source: Human
• Tag: GST
• Protein Length: 1-274 a.a.
• Description: PDCD1LG2 (B7-DC, CD273), is part of the B7 family of proteins. PDCD1LG2 plays an important regulatory role during the immune response of the host to the pathogen. PDCD1LG2 is a marker of angioimmunoblastic T-cell lymphoma and B-cell small lymphocytic lymphoma/chronic lymphocytic leukemia. HRV-16 infection or exposure to dsRNA induces epithelial PDCD1LG2. PDCD1LG2 functions as an inhibitor to T cell activation. PDCD1LG2 negatively regulates human T cell activation and therefore acts an a candidate protein for immunotherapeutic approaches aimed to attenuate pathological immune responses.
• Form: PDCD1LG2 is supplied in 50mM Tris-Acetate, pH-7.5, 1mM EDTA and 20% Glycerol.
• Physical Appearance: Sterile Filtered clear solution.
• Storage: Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles.
• Pathways: Cell adhesion molecules (CAMs); Signaling in Immune system

Gene Information

• Gene Name: PDCD1LG2 programmed cell death 1 ligand 2 [ Homo sapiens ]
• Official Symbol: PDCD1LG2
• Synonyms: PDCD1LG2; programmed cell death 1 ligand 2; B7DC; Btdc; PDL2; CD273; PD-L2; PDCD1L2; MGC142238; MGC142240; bA574F11.2; PD-1-ligand 2; programmed death ligand 2
• Gene ID: 80380
• mRNA Refseq: NM_025239
• Protein Refseq: NP_079515
• MIM: 605723
• UniProt ID: Q9BQ51
• Chromosome Location: 9p24.2
• Function: molecular_function; protein binding; receptor activity