Active Recombinant Mouse Interleukin 17A, MIgG2a Fc-tagged

Cat.No. : IL17A-001H
Product Overview : The extracellular domain of mouse IL-17 (NP_034682.1)(Met1-Leu142) is fused to the N-terminus of the Fc region of a mouse IgG2a was expressed in CHO cell.
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Species : Mouse
Source : CHO
Tag : Fc
Protein Length : 1-142 a.a.
Description : The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokineregulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate theexpression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO).High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoidarthritis, psoriasis and multiple sclerosis.
Form : Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity : Measured by its ability to induce IL-6 secretion .
Molecular Mass : 39KDa (monomer)
AA Sequence : Met1-Leu142
Endotoxin : <0.06 eu/μg="" as="" determined="" by="" lal="" test.="">
Purity : >98%, by SDS-PAGE under reducing conditions.
Stability : Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution : Reconstitute at 100μg/ml in sterile PBS.
Warning : Avoid freeze/thaw cycles.
Gene Name Il17a interleukin 17A [ Mus musculus ]
Official Symbol IL17A
Synonyms IL17A; interleukin 17A; interleukin-17A; cytotoxic T-lymphocyte-associated antigen 8; Il17; Ctla8; IL-17; Ctla-8; IL-17A;
Gene ID 16171
mRNA Refseq NM_010552
Protein Refseq NP_034682
Pathway Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Rheumatoid arthritis, organism-specific biosystem; Rheumatoid arthritis, conserved biosystem;
Function cytokine activity;

Not For Human Consumption!

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