Active Recombinant Mouse Insulin-Like Growth Factor Binding Protein 5

• Cat.No.: Igfbp5-5644M
• Product Overview: RecombinantMouse Igfbp5 protein was expressed in Murine myeloma cellline. Val15-Glu271.

Specification

• Species: Mouse
• Source: Mammalian Cells
• Tag: Non
• ProteinLength: 15-271 a.a.
• Description: Thesuperfamily of insulin-like growth factor (IGF) binding proteins include thesix high-affinity IGF binding proteins (IGFBP) and at least four additional low-affinitybinding proteins referred to as IGFBP related proteins (IGFBP-rP). All IGFBPsuperfamily members are cysteine-rich proteins with conserved cysteineresidues, which are clustered in the amino-and carboxy-terminal thirds of themolecule. IGFBPs modulate the biological activities of IGF proteins. SomeIGFBPs may also have intrinsic bioactivity that is independent of their abilityto bind IGF proteins. Post-translational modifications of IGFBPs, includingglycosylation, phosphorylation and proteolysis, have been shown to modify theaffinities of the binding proteins to IGF.
• Form: Suppliedas a 0.2 um filtered solution in Acetonitrile and TFA.
• N-terminalSequence: Val15
• MolecularWeight: 28.9 kDa
• Activity: Measuredby its ability to inhibit the biological activity of IGF-I or IGF-II on MCF-7human breast adenocarcinoma cells. The ED50 for this effect is typically 0.5-2.5μg/mL in the presence of 30 ng/mL of rmIGF-II.
• Endotoxin Level: <1.0EU per 1μg of the protein by the LAL method.
• SDS-PAGE: 28-38kDa triplet, reducing conditions.
• Purity: >90%,by SDS-PAGE under reducing conditions and visualized by silver stain.
• Reconstitution: 100 μg/mLin sterile PBS
• Storage: Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied.1 month, 2 to 8°C under sterile conditions after reconstitution. 3months, -20 to -70°C under sterile conditions after reconstitution.

Gene Information

• Gene Name: Igfbp5 insulin-like growthfactor binding protein 5 [ Mus musculus ]
• Official Symbol: Igfbp5
• Synonyms: Igfbp5; insulin-likegrowth factor binding protein 5; IGFBP-5;AI256729; AW208790; IGFBP-5P; insulin-like growth factor-binding protein 5;IBP-5; IGF-binding protein 5; Insulin-like growth factor binding protein 5, isoform CRA_a
• Gene ID: 16011
• mRNA Refseq: NM_010518
• Protein Refseq: NP_034648
• UniProt ID: Q3UQV0
• Chromosome Location: 1
• Pathway: Diabetes pathways;Disease; Myometrial Relaxation and Contraction Pathways; Regulation ofInsulin-like Growth Factor (IGF) Activity by Insulin-like Growth FactorBinding Proteins (IGFBPs)
• Function: fibronectin binding;growth factor binding; insulin-like growth factor I binding; insulin-likegrowth factor binding