Active Recombinant Mouse Ifna2

• Cat.No.: Ifna2-15M
• Product Overview: Recombinant Mouse Ifna2 (amino acids Cys24-Glu190 of mature mouse IFN alpha2 accession # NM_010503) was expressed in E. coli.

Specification

• Species: Mouse
• Source: E.coli
• Tag: Non
• Protein Length: 24-190 a.a.
• Description: IFN-α2 is a type I interferon, previously known as B-cell interferon, leukocyte interferon, lymphoblast interferon, and pH2-stable interferon. IFN-α2 is one of at least 23 different known variants of IFN-α. The individual proteins have molecular masses between 19-26 kDa and consist of proteins with lengths of 156-166 and 172 amino acids. IFN-α forms are produced by monocytes/macrophages, lymphoblastoid cells, fibroblasts, and a number of different cell types following induction by viruses, nucleic acids, glucocorticoid hormones, and low-molecular weight substances (n-butyrate, 5-bromodeoxyuridine). IFN-α2 demonstrates antiviral, antiparasitic, antiproliferative activities.
• Form: Sterile liquid; 50mM NaAc, 0.1M NaCl, 0.5% BSA, pH 5.0.
• Bio-activity: The recombinant mouse IFN alpha2 has been tested for inhibition of the cytopathic effect of EMC virus on L929 cells. The ED50 for this effect is typically 0.1 ng/mL, corresponding to a specific activity of 1 x 10e7 Units/mg.
• Molecular Mass: The protein has a predicted molecular mass of 19,361. The non-reduced protein migrates as a 16 kDa polypeptide on SDS-PAGE. The DTT reduced protein migrates as an 18 kDa polypeptide.
• Endotoxin: Less than 0.01 ng/ug cytokine as determined by the LAL assay.
• Purity: > 98% as determined by SDS-PAGE
• Applications: Cytokine Bioassays
• Storage: Store at less than or equal to -70°C.

Gene Information

• Gene Name: Ifna2 interferon alpha 2 [ Mus musculus (house mouse) ]
• Official Symbol: Ifna2
• Synonyms: Ifna2; Ifa2; interferon alpha 2; interferon alpha-2; IFN-alpha-2; interferon alpha family, gene 2
• Gene ID: 15965
• mRNA Refseq: NM_010503
• Protein Refseq: NP_034633
• UniProt ID: P01573
• Chromosome Location: 4 C4; 4 42.02 cM
• Pathway: Autoimmune thyroid disease; Cytokine Signaling in Immune system; Cytokine-cytokine receptor interaction
• Function: cytokine activity; cytokine receptor binding; type I interferon receptor binding