Active Recombinant Mouse Cd40lg, FLAG-tagged
Cat.No. : | Cd40lg-404M |
Product Overview : | Mouse CD40L (aa 115-260) is fused at the N-terminus to mouse ACRP30headless (aa 18-111) and a FLAG-tag. |
- Specification
- Gene Information
- Related Products
- Download
Species : | Mouse |
Source : | CHO |
Tag : | Flag |
Protein Length : | 115-260;18-111 a.a. |
Description : | MegaCD40L is a high activity construct in which two trimeric CD40 ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively simulates the natural membrane-assisted aggregation of CD40L in vivo. It provides a simple and equally potent alternative to CD40L+enhancer combinations. MegaCD40L has shown to suppress alum-induced IL-1beta; release and caspase-1 activation in a dose-, CD40- and time dependent manner, without affecting BMDM (Bone marrow-derived macrophages) viability. It also effectively suppressed the inflammasome function triggered by NLRP3 activators. The secretion of caspase-1 independent inflammatory mediators has been shown to be unaltered or even enhanced. |
Form : | Lyophilized. Contains PBS. |
Bio-activity : | Induces B cells activation (as demonstrated by dose-dependent upregulation of CD86). |
Molecular Mass : | ~35-40kDa |
Purity : | ≥95% (SDS-PAGE) |
Stability : | Stable for at least 6 months after receipt when stored at -20°C. |
Storage : | Short Term Storage: +4°C; Long Term Storage: -20°C. After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. PBS containing at least 0.1% BSA should be used for further dilutions. |
Concentration : | 0.1mg/ml after reconstitution. |
Gene Name | Cd40lg CD40 ligand [ Mus musculus ] |
Official Symbol | Cd40lg |
Synonyms | CD40LG; CD40 ligand; T-cell antigen Gp39; TNF-related activation protein; tumor necrosis factor ligand superfamily member 5; IGM; IMD3; Ly62; TRAP; gp39; CD154; Cd40l; HIGM1; Ly-62; T-BAM; CD40-L; Tnfsf5; |
Gene ID | 21947 |
mRNA Refseq | NM_011616 |
Protein Refseq | NP_035746 |
Pathway | Adaptive Immune System, organism-specific biosystem; Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Asthma, organism-specific biosystem; Asthma, conserved biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; |
Function | CD40 receptor binding; cytokine activity; tumor necrosis factor receptor binding; |
◆ Recombinant Proteins | ||
CD40LG-166CAF647 | Recombinant Canine CD40LG Protein, Gly/Pro-tagged, Alexa Fluor 647 conjugated | +Inquiry |
CD40LG-26080TH | Recombinant Human CD40LG protein | +Inquiry |
Cd40lg-2063M | Active Recombinant Mouse Cd40lg Protein | +Inquiry |
CD40LG-5368H | Recombinant Human CD40LG protein, His-tagged | +Inquiry |
CD40LG-791R | Recombinant Rhesus monkey CD40LG protein, His-tagged | +Inquiry |
◆ Cell & Tissue Lysates | ||
CD40LG-001CCL | Recombinant Canine CD40LG cell lysate | +Inquiry |
CD40LG-1548MCL | Recombinant Mouse CD40LG cell lysate | +Inquiry |
CD40LG-1080CCL | Recombinant Cynomolgus CD40LG cell lysate | +Inquiry |
CD40LG-1205RCL | Recombinant Rat CD40LG cell lysate | +Inquiry |
CD40LG-1965HCL | Recombinant Human CD40LG cell lysate | +Inquiry |
Not For Human Consumption!
Inquiry
- Reviews
- Q&As
Ask a Question for All Cd40lg Products
Required fields are marked with *
My Review for All Cd40lg Products
Required fields are marked with *
0
Inquiry Basket