Active Recombinant Human ULBP1 Protein (Gly26-Pro215), C-Fc-tagged

• Cat.No.: ULBP1-04H
• Product Overview: Recombinant Human ULBP-1 Protein (Gly26-Pro215) with a Human IgG1 (Pro100-Lys330) Fc tag at C-terminus was expressed in Spodoptera frugiperda, Sf 21.

Specification

• Species: Human
• Source: S.frugiperda
• Tag: Fc
• Protein Length: Gly26-Pro215
• Description: The protein encoded by this gene is a ligand of natural killer group 2, member D (NKG2D), an immune system-activating receptor on NK cells and T-cells. Binding of the encoded ligand to NKG2D leads to activation of several signal transduction pathways, including those of JAK2, STAT5, ERK and PI3K kinase/Akt. Also, in cytomegalovirus-infected cells, this ligand binds the UL16 glycoprotein and is prevented from activating the immune system. Three transcript variants encoding different isoforms have been found for this gene.
• Form: Disulfide-linked homodimer
• Bio-activity: Measured by its ability to bind rhNKG2D/Fc Chimera in a functional ELISA.
• Molecular Mass: Predicted Molecular Mass: 48.8 kDa (monomer)
  SDS-PAGE: 55 kDa, reducing conditions
• N-terminal Sequence Analysis: Gly26
• Endotoxin: <0.10 EU/μg of the protein by the LAL method.
• Purity: >90%, by SDS-PAGE under reducing conditions and visualized by silver stain
• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  12 months from date of receipt, -20 to -70 centigrade as supplied.
  1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
  3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
• Storage Buffer: Lyophilized from a 0.2 μm filtered solution in PBS.
• Reconstitution: Reconstitute at 100 μg/mL in sterile PBS.
• Shipping: The product is shipped at ambient temperature.

Gene Information

• Gene Name: ULBP1 UL16 binding protein 1 [ Homo sapiens (human) ]
• Official Symbol: ULBP1
• Synonyms: ULBP1; UL16 binding protein 1; N2DL-1; RAET1I; NKG2DL1; UL16-binding protein 1; NKG2D ligand 1; alcan-beta; retinoic acid early transcript 1I
• Gene ID: 80329
• mRNA Refseq: NM_025218
• Protein Refseq: NP_079494
• MIM: 605697
• UniProt ID: Q9BZM6