Active Recombinant Human TRAP1, FLAG-tagged

• Cat.No.: TRAP1-8462H
• Product Overview: Recombinant human TRAP1 has a C-terminal FLAG tag and has 702 amino acid residues. It has been identified to be protective for cell survival, and has been suggested as a target for anti-cancer therapeutics. Also can be useful for studies including enzyme

Specification

• Species: Human
• Source: E.coli
• Tag: Flag
• Description: Human TRAP1 belongs to the mitochondrial heat shock protein family. These molecular chaperones are highly conserved and play an important role in signal transduction, protein folding and degradation.
• Form: 50 mM potassium phosphate pH 7.4, 50 mM sodium chloride, 0.5 mM DTT, 0.5 mM EDTA, and 2.5% glycerol.
• Bio-activity: Kd = 1.95 nM. Assay conditions: 20 mM HEPES, pH 7.5, 50 mM KCl, 5 mM MgCl2, 20 mM sodium molybdate, 2 mM DTT, 0.01% NP40, 100 µg/ml BSA, 50 nM TRAP1, geldanamycin-FITC (titration range 0.016-16 nM) incubated at 4oC for 24 hrs. Fluorescence polarizat
• Molecular Mass: 76.5 kDa
• Purity: ≥95% by SDS - PAGE
• Storage: The protein is best stored in working aliquots at -80 ℃. Avoid freeze/thaw cycles.
• Shipping: Dry Ice

Gene Information

• Gene Name: TRAP1 TNF receptor-associated protein 1 [ Homo sapiens ]
• Official Symbol: TRAP1
• Synonyms: TRAP1; TNF receptor-associated protein 1; heat shock protein 75 kDa, mitochondrial; HSP75; HSP90L; HSP 75; TRAP-1; TNFR-associated protein 1; tumor necrosis factor type 1 receptor associated protein; tumor necrosis factor type 1 receptor-associated protein
• Gene ID: 10131
• mRNA Refseq: NM_016292
• Protein Refseq: NP_057376
• MIM: 606219
• UniProt ID: Q12931
• Chromosome Location: 16p13.3
• Pathway: TGF-beta Receptor Signaling Pathway, organism-specific biosystem
• Function: ATP binding; nucleotide binding; tumor necrosis factor receptor binding; unfolded protein binding