TRAP1
-
Official Full Name
TNF receptor-associated protein 1 -
Overview
HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding,;protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play;important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress.;TRAP1 is a mitochondrial HSP90 protein. Other HSP90 proteins are found in cytosol (see HSP90AA1; MIM 140571) and;endoplasmic reticulum (HSP90B1; MIM 191175) (Chen et al., 2005 (PubMed 16269234)). -
Synonyms
TRAP1;TNF receptor-associated protein 1;heat shock protein 75 kDa, mitochondrial;HSP75;HSP90L;mitochondrial;Heat shock protein 75;Heat shock protein 75 kDa;Heat shock protein 75 kDa mitochondrial;HSP 75;HSP 90L;TNF receptor associated protein 1;TNFR associated protein 1;TNFR-associated protein 1;TRAP 1;TRAP-1;TRAP1_HUMAN;Tumor necrosis factor receptor associated protein;Tumor necrosis factor type 1 receptor associated protein;Tumor necrosis factor type 1 receptor-associated protein;OTTHUMP00000159796
Recombinant Proteins
- Human
- Chicken
- Mouse
- Rat
- Zebrafish
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- Yeast
- GST
- Flag
- His
- Non
- His&Myc
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TRAP1-3622H | Recombinant Human TRAP1 protein, GST-tagged | E.coli | Human | GST | 446-704 aa | |
| TRAP1-8462H |
Active Recombinant Human TRAP1, FLAG-tagged
|
E.coli | Human | Flag |
|
|
| TRAP1-1324C | Recombinant Chicken TRAP1 | Mammalian Cells | Chicken | His |
|
|
| TRAP1-17301M | Recombinant Mouse TRAP1 Protein | Mammalian Cells | Mouse | His |
|
|
| TRAP1-25H | Recombinant Human TRAP1 Protein, GST-tagged | Wheat Germ | Human | GST | 1 a.a. - 704 a.a. |
|
| TRAP1-2862H | Recombinant Human TRAP1, His-tagged | E.coli | Human | His | 60-704 a.a. |
|
| TRAP1-6260R | Recombinant Rat TRAP1 Protein | Mammalian Cells | Rat | His |
|
|
| TRAP1-6350Z | Recombinant Zebrafish TRAP1 | Mammalian Cells | Zebrafish | His |
|
|
| TRAP1-811HCL | Recombinant Human TRAP1 293 Cell Lysate | HEK293 | Human | Non |
|
|
| TRAP1-1533HF | Recombinant Full Length Human TRAP1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 704 amino acids |
|
| Trap1-454M | Recombinant Mouse Trap1 protein, His-tagged | Yeast | Mouse | His | 61-706aa |
|
| TRAP1-5201H | Recombinant Human TRAP1 protein, GST-tagged | E.coli | Human | GST | 60-308aa |
|
| Trap1-5363M | Recombinant Mouse Trap1 protein, His&Myc-tagged | E.coli | Mouse | His&Myc | 61-706a.a. |
|
| TRAP1-5917R | Recombinant Rat TRAP1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
|
|
| TRAP1-5917R-B | Recombinant Rat TRAP1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
|
||
| Trap1-6374M | Recombinant Mouse Trap1 Protein (Ser61-His706), N-His tagged | E.coli | Mouse | His | Ser61-His706 |
|
| TRAP1-9567M | Recombinant Mouse TRAP1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
|
|
| TRAP1-9567M-B | Recombinant Mouse TRAP1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
|
Involved Pathway
TRAP1 involved in several pathways and played different roles in them. We selected most pathways TRAP1 participated on our site, such as TGF-beta Receptor Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| TGF-beta Receptor Signaling Pathway | STK11IP,TGFBR3,CITED1,CTCF,SKIA,VDRB,SNIP1,FOXH1,HOXD9A,GIPC1 |
Protein Function
TRAP1 has several biochemical functions, for example, ATP binding,poly(A) RNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRAP1 itself. We selected most functions TRAP1 had, and list some proteins which have the same functions with TRAP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ARHGEF38,CRTAC1,UHRF2,NELL1,TBL3,GPC3,HMOX1,TNFAIP8,PTPRC,NEDD8 |
| tumor necrosis factor receptor binding | TNFSF14,ERAP1,TNFSF15,TNFSF12,CASP8,TNFSF13,CD70,LTA,TRAF2,TNFSF4 |
| ATP binding | PTK6,ERN1,ASS1,UBE2QL1,TRIP13,PIKFYVE,BTK,ASNA1,CDK5,IKBKB |
| unfolded protein binding | CDC37L1,GRPEL1,CHAF1B,DNAJB1A,DNAJB13,HSPA8,HSPA1A,HSP90AB1,NAP1L4,HSPA2 |
| protein kinase binding | WAS,ZC3HC1,PPP1CB,RPS6,FAF1,JIP1,TRIB3,CCNT2B,LIMS1,AP1B1 |
| poly(A) RNA binding | LSM3,MKRN1,PPIL4,SSBP1,RPS12,PPP1R10,HNRNPR,PRDX1,FLYWCH2,WDR46 |
Interacting Protein
TRAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRAP1.
shepherdin_peptide;HLA-B;YWHAZ;Bles03;TPM3;q8ckx2_yerpe;ESX1;ileS;15-deoxy-delta(12,14;ere_dna;KIF2A;C1qbp;GABARAP;MYC;FN1;1C;CDK4;H2AFX;VCAM1
Resources
Related Services
Related Products
References
- Fismen, S; Thiyagarajan, D; et al. Impact of the Tumor Necrosis Factor Receptor-Associated Protein 1 (Trap1) on Renal DNaseI Shutdown and on Progression of Murine and Human Lupus Nephritis. AMERICAN JOURNAL OF PATHOLOGY 182:688-700(2013).
- Nguyen, MC; Tu, GH; et al. Antibody responses to galectin-8, TARP and TRAP1 in prostate cancer patients treated with a GM-CSF-secreting cellular immunotherapy. CANCER IMMUNOLOGY IMMUNOTHERAPY 59:1313-1323(2010).
Reviews
This data looks promising and we have one more assay to perform as a check. If this meets expectations we will be looking to purchase a larger amount of the protein.
