Active Recombinant Human transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) Protein, His-tagged

• Cat.No.: TGM2-628H
• Product Overview: Active Recombinant Human TGM2 Protein (2-687aa) with His tag was expressed in Insect cells.

Specification

• Description: Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene.
• Source: Insect cells
• Species: Human
• Tag: His
• Protein length: 2-687aa
• Bio-activity: Measured by its ability to cleave a synthetic peptide Benzyloxycarbonyl Gln Gly and NH2OH. The specific activity is > 1000 pmol/min/μg
• Molecular Mass: 78 kDa
• Endotoxin: < 1 EU/μg by LAL.
• Purity: > 95 % by SDS-PAGE
• Stability: 6 months from date of receipt, -80 centigrade as supplied.
  3 months, -80 centigrade under sterile conditions after opening
• Storage: Store it under sterile conditions at -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Concentration: 0.5 mg/mL
• Storage Buffer: Supplied as a 0.2 μm filtered solution in 50 mM Tris, pH 7.5, 150 mM NaCl, 0.25mM DTT, and 10 % glycerol.

Gene Information

• Gene Name: TGM2 transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) [Homo sapiens (human)]
• Official Symbol: TGM2
• Synonyms: TGM2; transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase); protein-glutamine gamma-glutamyltransferase 2; TGC; TG(C); TGase C; TGase H; TGase-2; TGase-H; C polypeptide; transglutaminase C; transglutaminase H; transglutaminase-2; tissue transglutaminase; protein-glutamine-gamma-glutamyltransferase; TG2; GNAH; G-ALPHA-h
• Gene ID: 7052
• mRNA Refseq: NM_004613
• Protein Refseq: NP_004604
• MIM: 190196
• UniProt ID: P21980