Recombinant Human TGM2, His-tagged

• Cat.No.: TGM2-9173H
• Product Overview: Recombinant human TGM2 protein, fused to His-tag, was expressed in E. coli and purified by His-tag affinity chromatography , Superdex-200, RT-HPLC.

Specification

• Description: Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Liquid. 1×PBS
• Molecular Mass: 77.3KDa
• Protein length: 1-687 amino acids
• Purity: >99% as determined by RT-HPLC
• Storage: Can be stored at 4℃ for short term (1-2 weeks). For long term storage, store at -20℃ or -70℃
• Concentration: 0.35mg/ml

Gene Information

• Gene Name: TGM2 transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) [ Homo sapiens ]
• Official Symbol: TGM2
• Synonyms: TGM2; transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase); protein-glutamine gamma-glutamyltransferase 2; TGC; TG(C); TGase C; TGase H; TGase-2; TGase-H; C polypeptide; transglutaminase C; transglutaminase H; transglutaminase-2; tissue transglutaminase; protein-glutamine-gamma-glutamyltransferase; TG2; GNAH; G-ALPHA-h
• Gene ID: 7052
• mRNA Refseq: NM_004613
• Protein Refseq: NP_004604
• MIM: 190196
• UniProt ID: P21980
• Chromosome Location: 20q12
• Pathway: Huntingtons disease, organism-specific biosystem; Huntingtons disease, conserved biosystem; Thromboxane A2 receptor signaling, organism-specific biosystem
• Function: GTP binding; metal ion binding; protein binding; protein domain specific binding; protein-glutamine gamma-glutamyltransferase activity; transferase activity, transferring acyl groups