Description :	TRKA is a member of the neurotrophic tyrosine kinase receptor (NTKR) family which is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. TRKA has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermoregulation via sweating in humans. The oncogenic rearrangement of 5′TPM3-3′NTRK1 fusion gene has been found in papillary thyroid carcinomas.
Source :	Sf9 insect cells using baculovirus
Species :	Human
Tag :	GST
Form :	50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.
Bio-activity :	12 nmol/min/mg
Molecular Mass :	~105 kDa
Purity :	>70% by densitometry
Applications :	Kinase Assay
Storage :	Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration :	0.05 ug/ul
Protein length :	1-258;399-end a.a.

Gene Name	TPM3 tropomyosin 3 [ Homo sapiens ]
Official Symbol	TPM3
Synonyms	TPM3; tropomyosin 3; NEM1; tropomyosin alpha-3 chain; TRK; tropomyosin-3; tropomyosin-5; gamma-tropomyosin; tropomyosin gamma; cytoskeletal tropomyosin TM30; heat-stable cytoskeletal protein 30 kDa; TM3; TM5; CFTD; TM-5; TM30; hTM5; TM30nm; TPMsk3; hscp30; OK/SW-cl.5; MGC3261; FLJ41118; MGC14582; MGC72094;
Gene ID	7170
mRNA Refseq	NM_001043351
Protein Refseq	NP_001036816
MIM	191030
UniProt ID	P06753
Chromosome Location	1q21.2
Pathway	Cardiac muscle contraction, organism-specific biosystem; Cardiac muscle contraction, conserved biosystem; Dilated cardiomyopathy, organism-specific biosystem; Dilated cardiomyopathy, conserved biosystem; Hypertrophic cardiomyopathy (HCM), organism-specific biosystem; Hypertrophic cardiomyopathy (HCM), conserved biosystem; Muscle contraction, organism-specific biosystem;
Function	actin binding; molecular_function;

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COA

Cat.No. :	TPM3-94H
Product Overview :	Recombinant human fusion protein TPM3 (1-258)-TRKA (399-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Active Recombinant Human TPM3+TRKA co-expressed protein, GST-tagged