TPM3
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Official Full Name
tropomyosin 3 -
Overview
This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Mutations in this gene result in autosomal dominant nemaline myopathy, and oncogenes formed by chromosomal translocations involving this locus are associated with cancer. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
TPM3;tropomyosin 3;NEM1;tropomyosin alpha-3 chain;TRK;tropomyosin-3;tropomyosin-5;gamma-tropomyosin;tropomyosin gamma;cytoskeletal tropomyosin TM30;heat-stable cytoskeletal protein 30 kDa;TM3;TM5;CFTD;TM-5;TM30;hTM5;TM30nm;TPMsk3;hscp30
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Chicken
- Rhesus macaque
- Rat
- E.coli
- Sf9 Cells
- Mammalian Cells
- HEK293
- Insect Cells
- GST
- His
- Non
- DDK
- Myc
- T7
- Avi
- Fc
- Flag
Involved Pathway
TPM3 involved in several pathways and played different roles in them. We selected most pathways TPM3 participated on our site, such as Cardiac muscle contraction,Adrenergic signaling in cardiomyocytes,Pathways in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with TPM3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hypertrophic cardiomyopathy (HCM) | ITGA6,ITGA7,SGCG,CACNB4,MYBPC3,CACNB3,ITGA2,TPM4,PRKAB2,ITGA5 |
| Cardiac muscle contraction | CACNG8,COX5AA,COX6A2,ATP1B3A,ATP1A3B,TPM4A,CACNA1C,COX4I1,ATP1A1,UQCRC2B |
| Adrenergic signaling in cardiomyocytes | PRKACB,BCL2A,CAMK2G,KCNE1,GNAI3,CREB3L1,PPP2CB,CREB3L3L,TPM4,ADCY9 |
| Thyroid cancer | RXRG,LEF1,NRAS,KRAS,CDH1,PAX8,PPARG,NCOA4,CCND1,TCF7 |
| Pathways in cancer | PLCB1,ETS1,SMO,Ar,F2R,Kitl,CBL,LAMA2,TGFA,MAP2K2 |
| Dilated cardiomyopathy | RYR2,ACTG1,PLN,MYBPC3,CACNA2D3,ATP2A2,ITGB4,ITGB8,SGCB,TTN |
Protein Function
TPM3 has several biochemical functions, for example, actin binding,molecular_function,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TPM3 itself. We selected most functions TPM3 had, and list some proteins which have the same functions with TPM3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | RAMP1,TUBB,TTC19,PIH1D2,CPNE3,GIP,C19orf25,RAB34,CCDC85B,NOL11 |
| molecular_function | KRTCAP2,G6b,GM239,GM6710,CNNM2,CCDC6A,ARL14EPL,SERF2,PCED1B,TMEM14A |
| actin binding | DST,TNNI1,ESPN,ANLN,SYN1,MKL1B,UPF3B,MYO1G,TWF2B,SHROOM4 |
Interacting Protein
TPM3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TPM3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TPM3.
KXD1;MAD1L1;IKBKE;374666;TFPT;OIP5;LCA5L
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