Active Recombinant Human Thrombomodulin, His-tagged

• Cat.No.: THBD-2602H
• Product Overview: Recombinant Human THBD (Ala19­Ser515) fused with a C­terminal and 6­His tag, was expressed in Mouse NSO Cells.

Specification

• Source: Mammalian Cells
• Tag: His
• Description: The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia.
• Molecular Mass: 53 kDa
• Predicted N terminal: Ala19
• Formulation: Supplied as a 0.2 μm filtered solution in Tris and NaCl.
• Purity: >95%, by SDS­PAGE under reducing conditions and visualized by silver stain.
• Activity: Measured by its ability to mediate thrombin activation of protein C. The specific activity is >50 pmol/min/µg, as measured under the described conditions.
• EndotoxinLevel: <1.0 EU per 1 μg of the protein by the LAL method.
• Storage: 6 months from date of receipt, ­20 to ­70 °C as supplied. Avoid repeated freeze­thaw cycles.
• OfficialSymbol: THBD

Gene Information

• Gene Name: THBD thrombomodulin [ Homo sapiens ]
• Synonyms: THBD; thrombomodulin; TM; THRM; AHUS6; CD141; fetomodulin; CD141 antigen
• Gene ID: 7056
• mRNA Refseq: NM_000361
• Protein Refseq: NP_000352
• MIM: 188040
• UniProt ID: P07204
• Chromosome Location: 20p11.2
• Pathway: Complement and coagulation cascades; Hemostasis
• Function: calcium ion binding; protein binding; receptor activity; transmembrane receptor activity