THBD
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Official Full Name
thrombomodulin -
Overview
Thrombomodulin (TM) is a transmembrane glycoprotein composed of 575 amino acids (molecular weight 75 kD with natural anticoagulant properties ( Wen et al, 1987 ). It is normally expressed by a restricted number of cells, such as endothelial and mesothelia -
Synonyms
THBD;thrombomodulin;CD141;fetomodulin;CD141 antigen;TM;THRM;AHUS6;BDCA3;THPH12
Recombinant Proteins
- Human
- Rabbit
- Mouse
- Dog
- Rat
- Rhesus macaque
- Mus musculus
- E.coli
- Mammalian Cells
- HEK293
- Endothelial Cell Membrane
- CHO
- Human Cells
- His
- Non
- His&GST
- His&T7
- GST
- Flag
- His&KSI
- His&Fc&Avi
Involved Pathway
THBD involved in several pathways and played different roles in them. We selected most pathways THBD participated on our site, such as Complement and coagulation cascades, which may be useful for your reference. Also, other proteins which involved in the same pathway with THBD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Complement and coagulation cascades | C4BPB,PLAT,F13A1,PROC,MBL1,SERPINF2,SERPINA1A,BDKRB2,C2,C1S |
Protein Function
THBD has several biochemical functions, for example, calcium ion binding,protein binding,receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by THBD itself. We selected most functions THBD had, and list some proteins which have the same functions with THBD. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | CETN4,PPP3CB,KCNIP1,RCVRN,CBLC,AOC3,CETN3,NCS1,KCNIP2,ELTD1 |
| receptor activity | LILRA2,PVR,CCR6,MRC1,VMN1R44,CADM4,CD160,ANPEP,MED12,NLGN2 |
| protein binding | FAS,CALM1,NIPA2,TGFBRAP1,WDR92,SPAG8,RPL37A,MAD1L1,PPM1B,UBE2E2 |
| transmembrane signaling receptor activity | LILRB5,PTH1RB,OR2A4,CD97,NCR2,TNFRSF8,NPC1,CLEC4A,LGR4,OR4N4 |
Interacting Protein
THBD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with THBD here. Most of them are supplied by our site. Hope this information will be useful for your research of THBD.
F2;mdtB;dadA;PSENEN
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References
- Szarvas, N; Szilagyi, A; et al. First-line therapy in atypical hemolytic uremic syndrome: consideration on infants with a poor prognosis. ITALIAN JOURNAL OF PEDIATRICS 40:-(2014).
- Sinibaldi, S; Guzzo, I; et al. Post-transplant recurrence of atypical hemolytic uremic syndrome in a patient with thrombomodulin mutation. PEDIATRIC TRANSPLANTATION 17:E177-E181(2013).
