Active Recombinant Human SEMA5B, MIgG2a Fc-tagged

• Cat.No.: SEMA5B-001H
• Product Overview: The extracellular domain of human SEMA5B (AAH77726.1) (Val78-Thr834) is fused to the N-terminus of the Fc region of mouse lgG2a was expressed in CHO cell.

Specification

• Description: This gene encodes a member of the semaphorin protein family which regulates axon growth during development of thenervous system. The encoded protein has a characteristic Sema domain near the N-terminus, through whichsemaphorins bind to plexin, and five thrombospondin type 1 repeats in the C-terminal region of the protein. Theprotein product may be cleaved and exist as a secreted molecule (PMID: 19463192). Multiple transcript variantsencoding different isoforms have been found for this gene.
• Source: CHO cell
• Species: Human
• Tag: MIgG2a Fc-tagged
• Form: Lyophilized from 0.2μm-filtered solution in PBS.
• Bio-activity: Measured by the ability of the immobilized protein to support the adhesion of human pancreatic cancer cells.
• Molecular Mass: 110KDa (monomer)
• AA Sequence: Val78-Thr834
• Endotoxin: <0.06 eu/μg="" as="" determined="" by="" lal="" test.="">
• Purity: >98%, by SDS-PAGE under reducing conditions.
• Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
• Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
• Warning: Avoid freeze/thaw cycles.
• Protein length: 78-834 a.a.

Gene Information

• Gene Name: SEMA5B sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B [ Homo sapiens ]
• Official Symbol: SEMA5B
• Synonyms: SemG; SEMAG
• Gene ID: 54437
• mRNA Refseq: NM_001256348.1
• Protein Refseq: NP_001243277.1
• MIM: 609298
• UniProt ID: Q9P283
• Chromosome Location: 3q21.1
• Pathway: Axon guidance, organism-specific biosystem;Axon guidance, conserved biosystem
• Function: receptor activity