Active Recombinant Human PRKD2(G870E), GST-tagged

• Cat.No.: PRKD2-204H
• Product Overview: Recombinant full-length human PKD2 (G870E) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Description: PKD2 or polycystic kidney disease 2 is a member of the polycystin protein family which is a multi-pass membrane protein that functions as a calcium permeable cation channel, and is involved in calcium transport and calcium signaling in renal epithelial cells. PKD2 interacts with polycystin 1 and this complex may be partners in a common signaling cascade involved in tubular morphogenesis. PKD2 may function as a chaperone-like molecule, which may prevent ERAD of PKD2. PKD2 form an interaction network with PKD1 as the rate-limiting component.
• Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Bio-activity: The specific activity of PKD2 (G870E) was determined to be 540 nmol /min/mg
• Molecular Mass: ~130 kDa
• Purity: >90% by densitometry
• Applications: Kinase Assay, Western Blot
• Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.1 μg/μl

Gene Information

• Gene Name: PRKD2 protein kinase D2 [ Homo sapiens ]
• Official Symbol: PRKD2
• Synonyms: PRKD2; protein kinase D2; serine/threonine-protein kinase D2; DKFZP586E0820; HSPC187; PKD2; nPKC-D2
• Gene ID: 25865
• mRNA Refseq: NM_001079880
• Protein Refseq: NP_001073349
• MIM: 607074
• UniProt ID: Q9BZL6
• Chromosome Location: 19q13.2
• Pathway: T Cell Receptor Signaling Pathway, organism-specific biosystem
• Function: ATP binding; metal ion binding; nucleotide binding; protein binding; protein kinase C activity; protein kinase activity; protein serine/threonine kinase activity; protein serine/threonine kinase activity