PRKD2
-
Official Full Name
protein kinase D2 -
Overview
The protein encoded by this gene belongs to the protein kinase D (PKD) family of serine/threonine protein kinases. This kinase can be activated by phorbol esters as well as by gastrin via the cholecystokinin B receptor (CCKBR) in gastric cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms. -
Synonyms
PRKD2;protein kinase D2;serine/threonine-protein kinase D2;DKFZP586E0820;HSPC187;PKD2;nPKC-D2
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Insect Cells
- Sf9 Cells
- Mammalian Cells
- HEK293
- Sf21 Cells
- GST
- GST&His
- His
- His&T7
- Non
- DDK&Myc
- Avi&Fc&His
Involved Pathway
PRKD2 involved in several pathways and played different roles in them. We selected most pathways PRKD2 participated on our site, such as Rap signaling pathway,Aldosterone synthesis and secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Aldosterone synthesis and secretion | ADCY3,PLCB2,CALM1,PRKACG,PRKD3,KCNK3,ATF4,CALM4,NR4A2,LDLR |
| Rap signaling pathway | LPAR5,SIPA1L2,ANGPT4,DOCK4,FGF10,VASP,FGF22,ITGAL,PRKCA,SIPA1L1 |
Protein Function
PRKD2 has several biochemical functions, for example, ATP binding,metal ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKD2 itself. We selected most functions PRKD2 had, and list some proteins which have the same functions with PRKD2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | MTRR,MXD4,RAD23A,PGK1,PLEKHG2,SNX3,KLF3,FOXB1,OSTB,KRTAP10-11 |
| ATP binding | LIMK2,DCKL1B,KHK,CAD,ETNK1,NLRP4B,IGF1RA,NLK,PSMC1,EIF4A2 |
| protein kinase activity | ARAF,LTK,IKBKB,PTK2,TGFBR1,PRKCBB,PKN3,CLK2A,MAP2K5,PLK1 |
| protein kinase C activity | PRKCH,PRKCBA,PRKCA,PRKCB,PRKCHB,PRKD1,PRKCQ,PKN1,PKN2,PRKCI |
| protein serine/threonine kinase activity | MAP3K2,PRKDC,CAMK2B1,CAMK2D2,MOS,MAP2K3,SNRK,STK30,PRKAA2,CSNK1G1 |
| metal ion binding | AARS,KIT,NFS1,NUFIP1,DPEP3,DMRTA2,C1GALT1,ZNF558,KCND2,SMYD1B |
Interacting Protein
PRKD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKD2.
HDAC7;CSNK1A1;ARFIP1;q59fj7_human;CSNK1E;XPO1;HSP90AB1;CHM;YWHAH;CASK;PFDN1;GLRX3;SNRNP70;RARB;RXRA
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References
- Nomura, S; Bouhadana, M; et al. Noradrenalin and dopamine receptors both control cAMP-PKA signaling throughout the cerebral cortex. FRONTIERS IN CELLULAR NEUROSCIENCE 8:-(2014).
- Atsaves, V; Lekakis, L; et al. The oncogenic JUNB/CD30 axis contributes to cell cycle deregulation in ALK plus anaplastic large cell lymphoma. BRITISH JOURNAL OF HAEMATOLOGY 167:514-523(2014).
