Active Recombinant Human PIK3C2B protein, GST-tagged

• Cat.No.: PIK3C2B-164H
• Product Overview: Recombinant Human PIK3C2B(850-end) fused with an N-terminal GST tag was expressed in Insect cells.

Specification

• Description: PIK3C2B or phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta belongs to the phosphoinositide 3-kinase (PI3K) family. PIK3C2B plays a role in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. PIK3C2B is highly expressed in thymus and placenta and it may function in a calcium-independent manner. In cell signaling, PIK3C2B stabilizes nucleotide-free Ras and the interaction of Ras and PI3KC2beta mutually inhibits one another activity.
• Source: Insect cells
• Species: Human
• Tag: GST
• Form: 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Bio-activity: 100 nmol/min/mg
• Molecular Mass: 98 kDa
• Purity: >70%
• Applications: Kinase Assay
• Stability: 1 year at -70 centigrade from the date of shipment
• Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.1μg/μl
• Protein length: 850-end a.a.

Gene Information

• Gene Name: PIK3C2B phosphoinositide-3-kinase, class 2, beta polypeptide [ Homo sapiens ]
• Official Symbol: PIK3C2B
• Synonyms: PIK3C2B; phosphoinositide-3-kinase, class 2, beta polypeptide; phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit beta; C2 PI3K; PI3K C2beta; PI3K-C2beta; PI3K-C2-beta; PTDINS-3-kinase C2 beta; ptdIns-3-kinase C2 subunit beta; phosphoinositide 3-kinase-C2-beta; phosphatidylinositol 3-kinase C2 domain-containing beta polypeptide; C2-PI3K; DKFZp686G16234
• Gene ID: 5287
• mRNA Refseq: NM_002646
• Protein Refseq: NP_002637
• MIM: 602838
• UniProt ID: O00750
• Chromosome Location: 1q32
• Pathway: 3-phosphoinositide biosynthesis, organism-specific biosystem; 3-phosphoinositide biosynthesis, conserved biosystem; EGFR1 Signaling Pathway, organism-specific biosystem; Inositol phosphate metabolism, organism-specific biosystem; Inositol phosphate metabolism, conserved biosystem; Metabolic pathways, organism-specific biosystem; Phosphatidylinositol signaling system, organism-specific biosystem
• Function: 1-phosphatidylinositol-3-kinase activity; 1-phosphatidylinositol-4-phosphate 3-kinase activity; ATP binding; lipid kinase activity; nucleotide binding; phosphatidylinositol binding; phosphotransferase activity, alcohol group as acceptor; protein binding