Active Recombinant Human PDE10A, GST-tagged

• Cat.No.: PDE10A-1610H
• Product Overview: Recombinant human PDE10A (71-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Description: The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene.?
• Source: Sf9 insect cells
• Species: Human
• Tag: GST
• Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Bio-activity: 92 nmol/min/mg
• Molecular Mass: ~102 kDa
• Protein length: 71-end
• Purity: >80%
• Applications: PDE Assay
• Stability: 1 yr at -70oC from date of shipment.
• Storage: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.1 ug/ul

Gene Information

• Gene Name: PDE10A phosphodiesterase 10A [ Homo sapiens ]
• Official Symbol: PDE10A
• Synonyms: PDE10A; phosphodiesterase 10A; FLJ11894; FLJ25677; HSPDE10A; OTTHUMP00000017586; phosphodiesterase 10A1 (PDE10A1); dJ416F21.1 (phosphodiesterase 10A); EC 3.1.4.17; EC 3.1.4.35
• Gene ID: 10846
• mRNA Refseq: NM_001130690
• Protein Refseq: NP_001124162
• MIM: 610652
• UniProt ID: Q9Y233
• Chromosome Location: 6q26
• Pathway: G alpha (s) signalling events; Purine metabolism; Signaling by GPCR
• Function: 3",5"-cyclic-GMP phosphodiesterase activity; cGMP-stimulated cyclic-nucleotide phosphodiesterase activity