Active Recombinant Human NRTN Protein

• Cat.No.: NRTN-090H
• Product Overview: The mature recombinant human Neurturin protein consists of 102 amino acids (96-197) without tag was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Protein Length: 96-197 a.a.
• Description: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein signals through the RET receptor tyrosine kinase and a GPI-linked coreceptor, and promotes survival of neuronal populations. A neurturin mutation has been described in a family with Hirschsprung Disease.
• Bio-activity: Measured in a cell proliferation assay using SH-SY5Y human neuroblastoma cells. The ED50 for this effect is typically 20-80 ng/mL.
• Molecular Mass: 23.6 kDa
• Product-Related Proteins: 96-197
• Endotoxin: < 0.1 EU/μg of the protein as determined by the LAL method
• Purity: > 95 % as determined by SDS-PAGE
• Storage: At -80 centigrade. Avoid repeated freeze-thaw cycles.
• Storage Buffer: PBS

Gene Information

• Gene Name: NRTN neurturin [ Homo sapiens (human) ]
• Official Symbol: NRTN
• Synonyms: NRTN; neurturin; NTN; neurturin; prepro-neurturin
• Gene ID: 4902
• mRNA Refseq: NM_004558
• Protein Refseq: NP_004549
• MIM: 602018
• UniProt ID: Q99748