Active Recombinant Human MLL3 protein, GST-tagged

• Cat.No.: MLL3-191H
• Product Overview: Recombinant Human MLL3(4689-end) fused with GST tag at N-terminal was expressed in Insect cells.

Specification

• Species: Human
• Source: Insect Cells
• Tag: GST
• ProteinLength: 4689-end
• Description: Histone-lysine N-methyltransferase 2C, also known as mixed-lineage leukemia 2 (MLL3) is the central component of the MLL2/3 complex, a coactivator complex of nuclear receptors involved in transcriptional coactivation. Deletion of the region harboring the MLL3 gene was found to be the most frequently recurrent chromosomal abnormality in acute myeloid leukemia.
• Form: 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Bio-activity: 1000 nmol/min/mg
• Molecular Mass: 51 kDa
• Purity: >85%
• Applications: Methyltransferase Assay
• Stability: 1 year at -70 centigrade from the date of shipment
• Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.1μg/μl

Gene Information

• Gene Name: MLL3 myeloid/lymphoid or mixed-lineage leukemia 3 [ Homo sapiens ]
• Official Symbol: MLL3
• Synonyms: MLL3; myeloid/lymphoid or mixed-lineage leukemia 3; histone-lysine N-methyltransferase MLL3; HALR; KIAA1506; KMT2C; ALR-like protein; homologous to ALR protein; lysine N-methyltransferase 2C; myeloid/lymphoid or mixed-lineage leukemia protein 3; histone-l
• Gene ID: 58508
• mRNA Refseq: NM_170606
• Protein Refseq: NP_733751
• MIM: 606833
• UniProt ID: Q8NEZ4
• Chromosome Location: 7q36
• Pathway: Lysine degradation, organism-specific biosystem; Lysine degradation, conserved biosystem
• Function: DNA binding; histone methyltransferase activity (H3-K4 specific); metal ion binding; methyltransferase activity; protein binding; transferase activity; zinc ion binding