Active Recombinant Human MAP4K3 protein, GST-tagged

Description :	GLK is a member of the STE20 family of serine/threonine protein kinases and contains N-terminal catalytic domain and C-terminal regulatory domain. GLK is upstream of the MEKK1 target and is stimulated by UV radiation and TNF-and can lead to the activation of the JNK signaling pathway. GLK can directly activate PKC-θ during TCR signaling and people with systemic lupus erythematosus show considerable enhanced GLK expression and activation of PKC-θ and the kinase IKK in T cells. GLK can act as a pro-apoptotic kinase which orchestrates activation of BAX via the concerted posttranscriptional modulation of PUMA, BAD, and BIM.
Source :	Insect cells
Species :	Human
Tag :	GST
Form :	50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Bio-activity :	92 nmol/min/mg
Molecular Mass :	~70 kDa
Purity :	> 70%
Applications :	Kinase Assay, Western Blot
Stability :	1 year at -70 centigrade from date of shipment.
Storage :	Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration :	0.05μg/μl
Protein length :	1-380 a.a.

Gene Name	MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 [ Homo sapiens ]
Official Symbol	MAP4K3
Synonyms	MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3; RAB8IPL1; GLK; MAPKKKK3; MEK kinase kinase 3; MAPK/ERK kinase kinase kinase 3; germinal center kinase-like kinase; germinal center kinase-related protein kinase; MEKKK 3;
Gene ID	8491
mRNA Refseq	NM_003618
Protein Refseq	NP_003609
MIM	604921
UniProt ID	Q8IVH8
Chromosome Location	2p22.3
Pathway	Insulin Signaling, organism-specific biosystem; MAPK signaling pathway, organism-specific biosystem; MAPK signaling pathway, organism-specific biosystem; MAPK signaling pathway, conserved biosystem; TNF receptor signaling pathway, organism-specific biosystem;
Function	ATP binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; small GTPase regulator activity;