MAP4K3
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Official Full Name
mitogen-activated protein kinase kinase kinase kinase 3 -
Overview
This gene encodes a member of the Ste20 family of serine/threonine protein kinases. The protein belongs to the subfamily that consists of members, such as germinal center kinase (GCK), that are characterized by an N-terminal catalytic domain and C-terminal regulatory domain. The kinase activity of the encoded protein can be stimulated by UV radiation and tumor necrosis factor-alpha. The protein specifically activates the c-Jun N-terminal kinase (JNK) signaling pathway. Evidence suggests that it functions upstream of mitogen-activated protein kinase kinase kinase 1 (MEKK1). This gene previously was referred to as RAB8-interacting protein-like 1 (RAB8IPL1), but it has been renamed mitogen-activated protein kinase kinase kinase kinase 3 (MAP4K3). -
Synonyms
MAP4K3;mitogen-activated protein kinase kinase kinase kinase 3;RAB8IPL1;GLK;MAPKKKK3;MEK kinase kinase 3;MAPK/ERK kinase kinase kinase 3;germinal center kinase-like kinase;germinal center kinase-related protein kinase;MEKKK 3
Recombinant Proteins
- Human
- Rat
- Mouse
- HEK293
- E.coli
- Insect Cells
- Mammalian Cells
- Human Cells
- DDK
- Myc
- His
- GST
- Non
- Flag
- Avi
- Fc
Involved Pathway
MAP4K3 involved in several pathways and played different roles in them. We selected most pathways MAP4K3 participated on our site, such as MAPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP4K3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | RAC3A,FGF1,MAP2K2A,FGF6B,DUSP8A,PPP3CC,FGF12A,PPP5C,MEF2CA,MEF2C |
Protein Function
MAP4K3 has several biochemical functions, for example, ATP binding,MAP kinase kinase kinase kinase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP4K3 itself. We selected most functions MAP4K3 had, and list some proteins which have the same functions with MAP4K3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | PNKP,LIG4,UBA7,SYN2A,SRMS,HSPA7,ABCC5,SGK2B,SCN8A,XYLB |
| protein kinase activity | EK1,PKN1B,STK35L,IRAK1,PRKDC,GC2,SOX9,CASKB,IRAK4,PRKACAB |
| protein serine/threonine kinase activity | TESK2,MAP3K10,ROCK1,RPS6KA3,CSNK1DB,CDK1,RPS6KB2,MAPK6,NEK2,WNK1 |
| protein binding | IPO11,HSPH1,NFKB2,KDM4A,TCF7,LTBP2,SPINLW1,NAV2,FHL3,CD84 |
| MAP kinase kinase kinase kinase activity | ALPK2,MAP4K6,MAP4K1,MAP4K5,MAP4K2 |
Interacting Protein
MAP4K3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP4K3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP4K3.
PRKCQ;Prkcq;LCP2;GRB2;N/A;NCK1;PCBP1;SH3RF1;COPS5
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References
- Hammond, DE; Hyde, R; et al. Quantitative Analysis of HGF and EGF-Dependent Phosphotyrosine Signaling Networks. JOURNAL OF PROTEOME RESEARCH 9:2734-2742(2010).
