Active Recombinant Human LTBR protein, Fc-tagged

• Cat.No.: LTBR-635H
• Product Overview: Recombinant Human LTBR(Gln31-Met225) fused with N-terminus of the Fc region of a mutant human IgG1 was expressed in CHO.

Specification

• Species: Human
• Source: CHO
• Tag: Fc
• Protein Length: Gln31-Met225
• Description: The LTβR activates two different NF-κB pathways that lead to distinct patterns of gene induction, including selected chemokines, and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTβR activates the classical NF-κB (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1β. However, LTβR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival.
• Form: Lyophilized from 0.2μm-filtered solution in PBS.
• Bio-activity: Measured by its binding ability in a functional ELISA.
• Molecular Mass: 50 KDa (monomer)
• Endotoxin: <0.06 EU/μg as determined by LAL test.
• Purity: >98%, by SDS-PAGE under reducing conditions.
• Storage: Stable for at least 1 year after receipt when stored at -20 centigrade. Working aliquots
  are stable for up to 3 months when stored at -20 centigrade.
• Reconstitution: Reconstitute at 100μg/ml in sterile PBS.

Gene Information

• Gene Name: LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) [ Homo sapiens ]
• Official Symbol: LTBR
• Synonyms: LTBR; lymphotoxin beta receptor (TNFR superfamily, member 3); D12S370; tumor necrosis factor receptor superfamily member 3; TNF R III; TNFCR; TNFR RP; TNFR2 RP; TNFRSF3; TNF-RIII; TNFR-III; lymphotoxin B receptor; lymphotoxin-beta receptor; TNFR superfamily, member 3; tumor necrosis factor C receptor; tumor necrosis factor receptor type III; tumor necrosis factor receptor 2-related protein; tumor necrosis factor receptor superfamily, member 3; CD18; TNFR-RP; TNFR2-RP; LT-BETA-R; TNF-R-III
• Gene ID: 4055
• mRNA Refseq: NM_002342
• Protein Refseq: NP_002333
• MIM: 600979
• UniProt ID: P36941
• Chromosome Location: 12p13
• Pathway: Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem; Intestinal immune network for IgA production, organism-specific biosystem; Intestinal immune network for IgA production, conserved biosystem
• Function: identical protein binding; protein binding; receptor activity