Active Recombinant Human LTBR, Fc Chimera

• Cat.No.: LTBR-746H
• Product Overview: Recombinant Human LTBR (Accession # NP_002333) was produced in Chinese Hamster Ovary cell line, CHO-derived.

Specification

• Species: Human
• Source: CHO
• Tag: Fc
• Predicted N Terminal: Ser28
• Form: Lyophilized from a 0.2 µm filtered solution in PBS.
• Bio-activity: Measured by its ability to inhibit Lymphotoxin alpha 1/beta 2-induced IL-8 secretion in A375 human melanoma cells. Degli-Esposti, M. et al. (1997) J. Immunol. 158:1756.The ED50 for this effect is typically 2-10 ng/mL in the presence of 10 ng/mL of Recombinant Human Lymphotoxin alpha 1/beta 2.
• Molecular Mass: Recombinant Human LTBR, Fc Chimera has a calculated MW of 48.5 kDa (monomer). In SDS-PAGE migrates as 60-66 kDa, reducing conditions.
• Purity: >95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Storage: Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4ºC); After reconstitution under sterile conditions for 3 months (-70ºC).

Gene Information

• Gene Name: LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) [ Homo sapiens ]
• Official Symbol: LTBR
• Synonyms: LTBR; lymphotoxin beta receptor (TNFR superfamily, member 3); D12S370; tumor necrosis factor receptor superfamily member 3; TNF R III; TNFCR; TNFR RP; TNFR2 RP; TNFRSF3; TNF-RIII; TNFR-III; lymphotoxin B receptor; lymphotoxin-beta receptor; TNFR superfamily, member 3; tumor necrosis factor C receptor; tumor necrosis factor receptor type III; tumor necrosis factor receptor 2-related protein; tumor necrosis factor receptor superfamily, member 3; CD18; TNFR-RP; TNFR2-RP; LT-BETA-R; TNF-R-III
• Gene ID: 4055
• mRNA Refseq: NM_002342
• Protein Refseq: NP_002333
• MIM: 600979
• UniProt ID: P36941
• Chromosome Location: 12p13