Active Recombinant Human JAK1 protein, GST-tagged

Description :	JAK1 is a member of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. JAK1 bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein that is involved in the interferon-alpha/beta and -gamma signal transduction pathways. JAK1 plays an essential and nonredundant role in promoting biologic responses induced by a select subset of cytokine receptors, including those in which JAK utilization is thought to be nonspecific.
Source :	Insect cells
Species :	Human
Tag :	GST
Form :	50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Bio-activity :	22 nmol/min/mg
Molecular Mass :	~108 kDa
Purity :	>75%
Applications :	Kinase Assay, Western Blot
Storage :	Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration :	0.1 ug/ul
Protein length :	438-end a.a.

Gene Name	JAK1 Janus kinase 1 [ Homo sapiens ]
Official Symbol	JAK1
Synonyms	JAK1; Janus kinase 1; JAK1B; tyrosine-protein kinase JAK1; JAK1A; JTK3;
Gene ID	3716
mRNA Refseq	NM_002227
Protein Refseq	NP_002218
MIM	147795
UniProt ID	P23458
Chromosome Location	1p32.3-p31.3
Pathway	Antiviral mechanism by IFN-stimulated genes, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; EGFR1 Signaling Pathway, organism-specific biosystem; HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem; Hepatitis C, organism-specific biosystem; Hepatitis C, conserved biosystem;
Function	ATP binding; growth hormone receptor binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; protein tyrosine kinase activity; protein tyrosine kinase activity;