Recombinant Human Janus Kinase 1, GST-tagged

• Cat.No.: JAK1-674H
• Product Overview: Recombinant Human Janus Kinase 1 with a GST Tag at N-terminal is expressed inBaculovirus.MW=62 kDa.

Specification

• Species: Human
• Source: Insect Cells
• Tag: GST
• Description: JAK1 is a human tyrosine kinase protein essential for signaling for certain type I and type II cytokines. It interacts with the common gamma chain (γc) of type I cytokine receptors, to elicit signals from the IL-2 receptor family (e.g. IL-2R, IL-7R, IL-9R and IL-15R), the IL-4 receptor family (e.g. IL-4R and IL-13R), the gp130 receptor family (e.g. IL-6R, IL-11R, LIF-R, OSM-R, cardiotrophin-1 receptor (CT-1R), ciliary neurotrophic factor receptor (CNTF-R), neurotrophin-1 receptor (NNT-1R) and Leptin-R). It is also important for transducing a signal by type I (IFN-α/β) and type II (IFN-γ) interferons, and members of the IL-10 family via type II cytokine receptors. Jak1 plays a critical role in initiating responses to multiple major cytokine receptor families. Loss of Jak1 is lethal in neonatal mice, possibly due to difficulties suckling.
• Purity: 73 %. The purity was assessed by SDS-PAGE/CBB staining.
• Buffer: 50 mM Tris-HCl, 150 mM NaCl, 0.05% Brij35, 1 mM DTT, 10% glycerol, pH7.5.
• Storage And Handling: Store at -80oC.Avoid repeating freeze-thaws.

Gene Information

• Gene Name: JAK1 Janus kinase 1 [ Homo sapiens ]
• Synonyms:
  JAK1; Janus kinase 1; JAK-1; Janus kinase 1 (a protein tyrosine kinase); tyrosine-protein kinase JAK1; JAK1A; JAK1B; JTK3; EC 2.7.10.2
• Gene ID: 3716
• mRNA Refseq: NM_002227
• Protein Refseq: NP_002218
• MIM: 147795
• UniProt ID: P23458
• Chromosome Location: 1p32.3-p31.3
• Pathway: Jak-STAT signaling pathway; Leishmaniasis; Pancreatic cancer; Pathways in cancer
• Function: ATP binding; Janus kinase activity; growth hormone receptor binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; protein tyrosine kinase activity; transferase activity