Active Recombinant Human Interleukin 9 Receptor, His-tagged

• Cat.No.: IL9R-5664H
• Product Overview: RecombinantHuman IL9R protein was expressed in Murine myeloma cell line. Val40-Pro270,with a C-terminal 10-His tag.

Specification

• Species: Human
• Source: Mammalian Cells
• Tag: His
• Protein Length: 40-270 a.a.
• Description: The specifichigh affinity functional IL9R complex consists of a ligand-specific IL9R (α) subunitand the common γ chain that is shared with the receptors for IL-2, IL-4, IL-7and IL-15. Both the IL9R subunit and the common γ chain are members of thehematopoietin receptor superfamily. The cDNAs encoding mouse and human IL-9receptors have been isolated. The deduced mouse and human transmembrane proteins,sharing 53% amino acid sequence identity, contain 468 and 533 amino acid residues,respectively. As a result of alternative splicing, cDNA clones encodingisoforms of IL9R, including a putative soluble form, have also been identified.
• Form: Lyophilized from a0.2 μm filtered solution in PBS and NaCl with BSA as a carrier protein.
• N-terminalSequence: Val40
• MolecularWeight: 27.4 kDa
• Activity: Measuredby its ability to inhibit the IL-9-dependent proliferation of MO7e human megakaryocyticleukemic cells. The ED50 for this effect is typically 1-4 μg/mL in thepresence of 5 ng/mL of rhIL-9.
• Endotoxin Level: <1.0EU per 1μg of the protein by the LAL method.
• SDS-PAGE: 38 kDa,reducing conditions.
• Purity: >95%,by SDS-PAGE under reducing conditions and visualized by silver stain.
• Reconstitution: 250 μg/mLin sterile PBS containing at least 0.1% human or bovine serum albumin
• Storage: Use a manual defrost freezer and avoid repeated freeze-thawcycles. 12 months from date of receipt, -20 to -70°C as supplied. 1month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to-70°C under sterile conditions after reconstitution.

Gene Information

• Gene Name: IL9R interleukin 9 receptor [ Homosapiens ]
• Official Symbol: IL9R
• Synonyms: IL9R; interleukin 9receptor; CD129;interleukin-9 receptor; IL-9R; IL-9 receptor; OTTHUMP00000024331;OTTHUMP00000024332
• Gene ID: 3581
• mRNA Refseq: NM_002186
• Protein Refseq: NP_002177
• MIM: 300007
• UniProt ID: Q01113
• Chromosome Location: Xq28 and Yq12
• Pathway: Cytokine-cytokine receptor interaction; Hematopoieticcell lineage; IL-9 Signaling Pathway; Jak-STAT signaling pathway
• Function: interleukin-9receptor activity; receptor activity