Active Recombinant Human Insulin-Like 3 (Leydig cell)
Cat.No. : | INSL3-384H |
Product Overview : | RecombinantHuman INSL3 protein was expressed in E. coli. Ala106-Tyr131(A chain) & Leu21-Ala55. |
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Species : | Human |
Source : | E.coli |
Tag : | Non |
Protein Length : | 106-131;21-55 a.a. |
Description : | INSL3 isa member of the insulin/relaxin superfamily. INSL3 is a secreted proteinproduced in high amounts by testicular Leydig cells, and in lower amounts by ovarianfollicular theca interna cells. As with other insulin/relaxin superfamilymembers, human INSL3 is synthesized as a preprohormone. The Prepro INSL3precursor is 131 amino acids (aa) in length. It is processed by a prohormoneconvertase to remove a 20 aa signal sequence and a 47 aa internal pro-, or C-peptidethat separates a 35 aa N-terminal B chain from a 26 aa C-terminal A chain. |
Form : | Lyophilizedfrom a 0.2 um filtered solution in PBS. |
N-terminalSequence : | Ala106 (A chain)& Leu21(B chain) |
MolecularWeight : | 2.8 kDa (A chain),3.3 kDa (B chain) |
Activity : | Measuredby its ability to induce cAMP accumulation in human RXFP2 transfected HEK293human embryonic kidney cells. The ED50 for this effect is typically 12.5-50 pg/mL. |
Endotoxin Level : | <1.0EU per 1μg of the protein by the LAL method. |
Purity : | >95%,by SDS-PAGE under reducing conditions and visualized by silver stain. |
Reconstitution : | Reconstituteat 100μg/mL in sterile PBS. |
Storage : | Use amanual defrost freezer and avoid repeated freezethaw cycles. 12 months from date of receipt, -20 to -70°C as supplied.1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months,-20 to -70°C under sterile conditions after reconstitution. |
Gene Name | INSL3 insulin-like 3 (Leydigcell) [ Homo sapiens ] |
Official Symbol | INSL3 |
Synonyms | INSL3; insulin-like3 (Leydig cell); RLF; RLNL; insulin-like 3; ley-I-L; relaxin-likefactor b; leydig insulin-like peptide; leydig insulin -like hormone |
Gene ID | 3640 |
mRNA Refseq | NM_005543 |
Protein Refseq | NP_005534 |
MIM | 146738 |
UniProt ID | P51460 |
Chromosome Location | 19p13.2-p12 |
Pathway | Class A/1 (Rhodopsin-like receptors);Cytokine Signaling in Immune system; G alpha (s) signalling events; GPCRdownstream signaling; GPCR ligand binding; Immune System; Interleukinreceptor SHC signaling; Interleukin-2 signaling; Interleukin-3, 5 and GM-CSFsignaling; Interleukin-7 signaling; Peptide ligand-binding receptors; Relaxinreceptors; Signal Transduction; Signaling by GPCR; Signaling by Interleukins |
Function | G-protein coupled receptor binding; hormoneactivity; insulin receptor binding; receptor binding |
◆ Recombinant Proteins | ||
INSL3-2736R | Recombinant Rat INSL3 Protein, His (Fc)-Avi-tagged | +Inquiry |
INSL3-3376H | Recombinant Human INSL3 Protein (Leu21-Tyr131), C-His tagged | +Inquiry |
INSL3-6512Z | Recombinant Zebrafish INSL3 | +Inquiry |
INSL3-384H | Active Recombinant Human Insulin-Like 3 (Leydig cell) | +Inquiry |
INSL3-1047H | Recombinant Human INSL3 protein, His & T7-tagged | +Inquiry |
◆ Cell & Tissue Lysates | ||
INSL3-5191HCL | Recombinant Human INSL3 293 Cell Lysate | +Inquiry |
Not For Human Consumption!
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