INSL3
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Official Full Name
insulin-like 3 (Leydig cell) -
Overview
The protein encoded by this gene is an insulin like hormone produced mainly in gonadal tissues in males and females. Studies of the mouse counterpart suggest that this gene may be involved in the development of urogenital tract and female fertility. It may also act as a hormone to regulate growth and differentiation of gubernaculum, and thus mediating intra-abdominal testicular descent. The mutations in this gene may lead to, but not a frequent cause of, cryptorchidism. -
Synonyms
INSL3;insulin-like 3 (Leydig cell);relaxin like factor , RLNL;insulin-like 3;MGC119818;MGC119819;RLF;ley-I-L;relaxin-like factor b;leydig insulin-like peptide;leydig insulin -like hormone;leydig insulin -like peptide;RLNL
Recombinant Proteins
- Human
- Rat
- Rhesus macaque
- Zebrafish
- Mouse
- Bovine
- E.coli
- Mammalian Cells
- HEK293
- N-His-GST
- N-His-TRxA
- His
- Non
- T7
- GST
- SUMO
- Avi
- Fc
- DDK
- Myc
- KSI
Involved Pathway
INSL3 involved in several pathways and played different roles in them. We selected most pathways INSL3 participated on our site, such as Class A/1 (Rhodopsin-like receptors),G alpha (s) signalling events,GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with INSL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| G alpha (s) signalling events | RAMP2,PTHLH,VIP2,CRHB,VIP,CRH,ADM2A,RXFP2B,RAMP3,CALCB |
| GPCR ligand binding | RGR,CRHB,PENKB,ZFPM2B,TAS2R3,NMS,EMR1,GPR68,PTH2,OPN4 |
| GPCR downstream signaling | GHRH,VIP2,RASGRP2,GPR18,RGS10,RLN2,APPB,CCR1,MGLL,QRFPR |
| Relaxin receptors | RXFP2,RLN3,INSL5,RLN2,RLN3A |
| Class A/1 (Rhodopsin-like receptors) | NPB,NMU,CHRM5,ADRB1,CXCR7B,GPR55A,GPBAR1,GPR55,FPR-RS6,PNOC |
| Peptide ligand-binding receptors | NMBA,EDN3,NMB,PPY,GAL,INSL5,HEBP1,NPSR1,NPS,SST1.1 |
| Signal Transduction | FAM13B,USP9X,HEYL,APOC2,THBS3B,OPN1LW2,RARGA,RBP3,RTN4A,SOX13 |
| Signaling by GPCR | PNOCB,TAS2R3,OXTRL,PRLH,OPN1SW1,NET1,FGD2,EMR2,SOUL3,NMBA |
Protein Function
INSL3 has several biochemical functions, for example, G-protein coupled receptor binding,hormone activity,insulin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by INSL3 itself. We selected most functions INSL3 had, and list some proteins which have the same functions with INSL3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| insulin receptor binding | PTPN11,FRS3,PIK3R1,INS2,IRS4,SNX1,GRB10,DOK1,IGF1R,DOK2 |
| hormone activity | UTS2A,ADCYAP1A,UCN2,FNDC5B,GH1,UTS2D,AGT,RETNLB,ADM2,PRL2C3 |
| receptor binding | P2RX7,LAMA3,SRPX2,PLG,WNT2BA,TNFSF14,CROT,DPP4,UCN2,DDO |
| G-protein coupled receptor binding | PPY,UCN3,POMC,SFTPB,UCN2,GNA12A,NPFF,GNAI2A,S1PR2,RSPO2 |
| protease binding | MBL1,INS1,F3,ECM1,ANXA2,BCL10,Casp3,THAP5,Cstb,ELANE |
Interacting Protein
INSL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INSL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of INSL3.
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References
- Guo, JJ; Li, XW; et al. The increased number of Leydig cells by di(2-ethylhexyl) phthalate comes from the differentiation of stem cells into Leydig cell lineage in the adult rat testis. TOXICOLOGY 306:9-15(2013).
- Sarraj, MA; Escalona, RM; et al. Fetal Testis Dysgenesis and Compromised Leydig Cell Function in Tgfbr3 (Betaglycan) Knockout Mice. BIOLOGY OF REPRODUCTION 82:153-162(2010).
