Active Recombinant Human Il9, HIgG1 Fc-tagged, mutant

• Cat.No.: Il9-001H
• Product Overview: The extracellular domain of human IL-9 (AAH66285.1)(Gln19-Ile144) is fused to the N-terminus of the Fc region of mutant human IgG1was expressed in CHO cell.

Specification

• Species: Human
• Source: CHO
• Tag: Fc
• Protein Length: 19-144 a.a.
• Description: The protein encoded by this gene is a cytokine that acts as a regulator of a variety of hematopoietic cells. Thiscytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin 9 receptor(IL9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokineto various biological processes. The gene encoding this cytokine has been identified as a candidate gene forasthma. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in thepathogenesis of bronchial hyperresponsiveness.
• Form: Lyophilized from 0.2μm-filtered solution in PBS.
• Bio-activity: Measured in a cell proliferation assay.
• Molecular Mass: 40KDa (monomer)
• AA Sequence: Gln19-Ile144
• Endotoxin: <0.06 eu/μg="" as="" determined="" by="" lal="" test.="">
• Purity: >98%, by SDS-PAGE under reducing conditions.
• Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
• Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
• Warning: Avoid freeze/thaw cycles.

Gene Information

• Gene Name: IL9 interleukin 9 [ Homo sapiens ]
• Official Symbol: Il9
• Synonyms: IL9; interleukin 9; interleukin-9; homolog of mouse T cell and mast cell growth factor 40; HP40; IL 9; P40; p40 cytokine; p40 T cell and mast cell growth factor; T cell growth factor p40; cytokine P40; T-cell growth factor p40; p40 T-cell and mast cell growth factor; IL-9
• Gene ID: 3578
• mRNA Refseq: NM_000590
• Protein Refseq: NP_000581
• MIM: 146931
• UniProt ID: P15248
• Chromosome Location: 5q31-q35
• Pathway: Asthma, organism-specific biosystem; Asthma, conserved biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; IL-9 Signaling Pathway, organism-specific biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem
• Function: cytokine activity; growth factor activity; interleukin-9 receptor binding