Active Recombinant Human il4, MIgG2a Fc-tagged, mutant

• Cat.No.: IL4-363H
• Product Overview: The extracellular domain of mouse IL-4 (NP_067258.1)(His21-Ser140) is fused to the N-terminus of the Fc portion of a mutant mouse IgG2a was expressed in CHO cell.

Specification

• Species: Mouse
• Source: CHO
• Tag: Fc
• Protein Length: 21-140 a.a.
• Description: The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
• Form: Lyophilized from 0.2μm-filtered solution in PBS.
• Bio-activity: Measured in a cell proliferation assay using HT-2 mouse T cells.
• Molecular Mass: 43 KDa (monomer)
• AA Sequence: His21-Ser140
• Endotoxin: <0.06 eu/μg="" as="" determined="" by="" lal="">
• Purity: >98%, by SDS-PAGE under reducing conditions.
• Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
• Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
• Warning: Avoid freeze/thaw cycles.

Gene Information

• Gene Name: Il4 interleukin 4 [ Mus musculus ]
• Official Symbol: IL4
• Synonyms: IL4; interleukin 4; interleukin-4; IGG1 induction factor; B-cell growth factor 1; B-cell stimulatory factor 1; lymphocyte stimulatory factor 1; B-cell IgG differentiation factor; Il-4; BSF-1
• Gene ID: 16189
• mRNA Refseq: NM_021283
• Protein Refseq: NP_067258
• Pathway: Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Asthma, organism-specific biosystem; Asthma, conserved biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem
• Function: cytokine activity; cytokine receptor binding; growth factor activity; interleukin-4 receptor binding