Active Recombinant Human IL21 Protein

• Cat.No.: IL21-735H
• Product Overview: Recombinant Human IL21 Protein is produced by E.coli expression system.

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Protein Length: 30-162 aa
• Description: IL-21, also known as Interleukin-21, is a T-helper cytokine that regulates humoral immunity and cell-mediated anti-tumor responses. It has broad immunoregulatory activity and can modulate both humoral and cell-mediated responses. It is important in the regulation of haematopoiesis and immune responses, and can influence lymphocyte development. It is produced by activated T cell, and it influences proliferation of T and B cells and cytolytic activity of natural killer cells. It may be a critical factor in the control of persistent viral infections. It has a potential predicating significance for survival Time in patients in the development of sporadic CRC. It binds to the IL-21R and can activate janus kinase JAK1, JAK3, STAT1, and STAT3 in EDgamma-16 cells. Recombinant human was expressed in E.coli and purified by using conventional chromatography techniques.
• Form: Liquid. Phosphate buffer saline (pH 7.4).
• Bio-activity: The activity is determined by IFN-g ELISA in a using NK-92 cell. The ED50 for this is less or equal to 4 ng/ml.
• Molecular Mass: 15.5 kDa
• AA Sequence: MQGQDRHMIR MRQLIDIVDQ LKNYVNDLVP EFLPAPEDVE TNCEWSAFSC FQKAQLKSAN TGNNERIINV SIKKLKRKPP STNAGRRQKH RLTCPSCDSY EKKPPKEFLE RFKSLLQKMI HQHLSSRTHG SEDS
• Endotoxin: < 1.0 EU per 1 ug of protein (determined by LAL method)
• Purity: > 95 % by SDS - PAGE
• Notes: For research use only. This product is not intended or approved for human, diagnostics or veterinary use.
• Storage: Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 or -70 centigrade. Avoid repeated freezing and thawing cycles.
• Concentration: 0.25 mg/ml (determined by Epoch assay)

Gene Information

• Gene Name: IL21 interleukin 21 [ Homo sapiens ]
• Official Symbol: IL21
• Synonyms: Interleukin-21 isoform 1; CVID11; IL-21; Za11; IL21
• Gene ID: 59067
• mRNA Refseq: NM_001207006
• Protein Refseq: NP_001193935
• MIM: 605384
• UniProt ID: Q9HBE4