Active Recombinant Human IL18BP Protein
Cat.No. : | IL18BP-252I |
Product Overview : | Recombinant Human IL18BP Protein without tag was expressed in CHO. |
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Species : | Human |
Source : | CHO |
Description : | Interleukin-18 binding protein, also known as IL-18BP and tadekinig-alfa, is a secreted glycoprotein that contains an Ig-like C2-type domain. It is expressed in heart, lung, placenta and spleen. IL-18BP functions as an inhibitor of the proinflammatory cytokine IL-18. It binds to IL-18, prevents the binding of IL-18 to its receptor, and thus blocks IL-18-induced IFN-gamma production. The complete Ig domain has been shown to mediate the binding and neutralizing properties. IFN-gamma is able to upregulate the expression of IL-18BP, indicating that IL-18 activity is regulated by a feedback mechanism through IL-18BP. |
Form : | Sterile Filtered White lyophilized (freeze-dried) powder. |
Bio-activity : | ED50 < 30 ng/mL, measured in a bioassay using KG-1 cells in the presence of 50 ng/mL Human IL-18. |
Molecular Mass : | 42-44 kDa, observed by reducing SDS-PAGE. |
AA Sequence : | TPVSQTTTAATASVRSTKDPCPSQPPVFPAAKQCPALEVTWPEVEVPLNGTLSLSCVACSRFPNFSILYWLGNGSFIEHLPGRLWEGSTSRERGSTGTQLCKALVLEQLTPALHSTNFSCVLVDPEQVVQRHVVLAQLWAGLRATLPPTQEALPSSHSSPQQQG |
Endotoxin : | < 0.2 EU/μg, determined by LAL method. |
Purity : | > 95% as analyzed by SDS-PAGE and HPLC. |
Storage : | Lyophilized recombinant Human IL-18BP remains stable up to 6 months at -80 centigrade from date of receipt. Upon reconstitution, Human IL-18BP should be stable up to 1 week at 4 centigrade or up to 2 months at -20 centigrade. |
Storage Buffer : | Lyophilized after extensive dialysis against PBS. |
Reconstitution : | Reconstituted in ddH2O or PBS at 100 μg/mL. |
Gene Name | IL18BP interleukin 18 binding protein [ Homo sapiens ] |
Official Symbol | IL18BP |
Synonyms | IL18BP; interleukin 18 binding protein; interleukin-18-binding protein; IL18BPa; MC51L 53L 54L homolog gene product; IL-18BP; tadekinig-alfa; MC51L-53L-54L homolog gene product; |
Gene ID | 10068 |
mRNA Refseq | NM_001039659 |
Protein Refseq | NP_001034748 |
MIM | 604113 |
UniProt ID | O95998 |
◆ Recombinant Proteins | ||
Il18bp-1577M | Recombinant Mouse Il18bp protein, His-tagged | +Inquiry |
IL18BP-135H | Recombinant Human IL18BP Protein, Thr31-Gly194, C-His-Avi tagged, Biotinylated | +Inquiry |
Il18bp-265M | Active Recombinant Mouse Il18bp, Fc Chimera | +Inquiry |
IL18BP-2237R | Recombinant Rhesus monkey IL18BP Protein, His-tagged | +Inquiry |
IL18BP-3165H | Recombinant Human IL18BP protein, His-tagged | +Inquiry |
◆ Cell & Tissue Lysates | ||
IL18BP-2918HCL | Recombinant Human IL18BP cell lysate | +Inquiry |
IL18BP-2674MCL | Recombinant Mouse IL18BP cell lysate | +Inquiry |
Not For Human Consumption!
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