Recombinant Human Histone Deacetylase 2, His-tagged

• Cat.No.: HDAC2-1699H
• Product Overview: Recombinant human HDAC2 protein was expressed with c-terminal His-tag in high-5 cells using baculovirus expression system and purified by using conventional chromatography techniques.

Specification

• Species: Human
• Source: Human
• Tag: His
• Description: HDAC2 belongs to the histone deacetylase family that act via the formation of large multiprotein complexes and are responsible for the deacetylation of lysine residues on the N-terminal region of the core histones. It forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. It also plays an important role in transcriptional regulation, cell cycle progression and developmental events.
• Concentration: 0.25 mg/ml
• Form: Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 20% glycerol, 0.1M NaCl, 1mM DTT and 0.1mM PMSF.
• Purity: > 85% by SDS - PAGE
• Sequence: 1-488 amino acids: MAYSQGGGKK KVCYYYDGDI GNYYYGQGHP MKPHRIRMTH NLLLNYGLYR KMEIYRPHKA TAEEMTKYHS DEYIKFLRSI RPDNMSEYSK QMQRFNVGED CPVFDGLFEF CQLSTGGSVA GAVKLNRQQT DMAVNWAGGL HHAKKSEASG FCYVNDIVLA ILELLKYHQR VLYIDIDIHH GDGVEEAFYT TDRVMTVSFH KYGEYFPGTG DLRDI
• Molecular Mass: 56.4 kDa (496aa)
• Applications: SDS-PAGE
• Storage: Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.

Gene Information

• Gene Name: HDAC2 histone deacetylase 2 [ Homo sapiens ]
• Official Symbol: HDAC2
• Synonyms: HDAC2; RPD3; YAF1; histone deacetylase 2; OTTHUMP00000040427; YY1-associated factor 1; transcriptional regulator homolog RPD3; EC 3.5.1.98; HD2
• Gene ID: 3066
• mRNA Refseq: NM_001527
• Protein Refseq: NP_001518
• MIM: 605164
• UniProt ID: Q92769
• Chromosome Location: 6q21
• Pathway: Cell cycle; Chronic myeloid leukemia; Notch signaling pathway; Gene Expression; Signalling by NGF
• Function: enzyme binding; histone deacetylase activity; hydrolase activity; specific transcriptional repressor activity; transcription activator activity; transcription factor activity; transcription factor binding