Active Recombinant Human CES2

• Cat.No.: CES2-1140H
• Product Overview: Recombinant Human CES2 was expressed in Baculovirus-Insect cells.

Specification

• Species: Human
• Source: BTI Insect Cell
• Tag: Non
• Bio-activity: Member of a serine esterase family that hydrolyze ester and amide bonds. Carboxylesterase 2 is an endoplasmic reticulum-bound hydrolase that plays a critical role in xenobiotic detoxification and activation for ester-containing therapeutics. Carboxylesterase 2 is also involved in the detoxification of drugs such as heroin and cocaine. This enzyme is thought to play a role in lipid metabolism.Carboxylesterase 2 human identifies the site containing a large alcohol and small acyl group. It shows less transesterification activity due to presence of conformational interference in active site.
• Molecular Mass: It has two glycosylation sites at 103 and 267 residues with molecular mass 60kDa.
• Applications: Carboxylesterase 2 may play a key role in biotransformation of a variety of ester containing drugs and prodrugs.
• Storage: −70ºC
• Shipping: dry ice

Gene Information

• Gene Name: CES2 carboxylesterase 2 [ Homo sapiens (human) ]
• Official Symbol: CES2
• Synonyms: CES2; carboxylesterase 2; iCE; CE-2; PCE-2; CES2A1; cocaine esterase; carboxylesterase 2 (intestine, liver); hCE-2; intestinal carboxylesterase; liver carboxylesterase-2; methylumbelliferyl-acetate deacetylase 2; NP_003860.2; EC 3.1.1.1; EC 3.1.1.56; EC 3.1.1.84; NP_932327.1
• Gene ID: 8824
• mRNA Refseq: NM_003869
• Protein Refseq: NP_003860
• MIM: 605278
• UniProt ID: O00748
• Chromosome Location: 16q22.1
• Pathway: Drug metabolism - other enzymes; E2F transcription factor network; Fluoropyrimidine Activity; Phase I, non P450
• Function: carboxylic ester hydrolase activity; methylumbelliferyl-acetate deacetylase activity