Active Recombinant Human CD207 Molecule, Langerin, His-tagged

• Cat.No.: CD207-5607H
• Product Overview: Recombinant Human CD207protein was expressed in Murine myeloma cell line with an N-terminal 9-Histag. Tyr64-Pro328.

Specification

• Species: Human
• Source: Mammalian Cells
• Tag: His
• Protein Length: 64-328 a.a.
• Description: CD207 is a type IItransmembrane glycoprotein which is member K of the C type lectin domainfamily 4. CD207 is used as a marker for Langerhans cells (LCs) whichrepresent the immature dendritic cells in the epidermis. LCs uniquely containtennis racket shaped endosomal recycling compartment subdomains withpentalamellar membranes termed Birbeck granules. CD207 is necessary andsufficient for Birbeck granule formation.
• Form: Lyophilized from a0.2 μm filtered solution in PBS.
• N-terminalSequence: His
• Molecular Weight: 31 kDa
• Activity: Measuredby its ability to bind biotinylated Mannose-Polyacrylamide in a functionalELISA. Valladeau, J. et al. (2000) Immunity 12:71.
• Endotoxin Level: <1.0 EUper 1 μg of the protein by the LAL method.
• SDS-PAGE: 35-40kDa, reducing conditions
• Purity: >95%,by SDS-PAGE under reducing conditions and visualized by silver stain.
• Reconstitution: Reconstituteat 100 μg/mL in sterile PBS
• Storage: Use a manualdefrost freezer and avoid repeated freeze-thaw cycles. 12 months from date ofreceipt, -20 to -70°C as supplied. 1 month, 2 to 8 °C under sterile conditionsafter reconstitution. 3 months, -20 to -70°C under sterile conditions after reconstitution.

Gene Information

• Gene Name: CD207 CD207 molecule, langerin[ Homo sapiens ]
• Official Symbol: CD207
• Synonyms: CD207; CD207molecule, langerin; CLEC4K; C-type lectin domain family 4 member K; CD207antigen, langerin; Langerhans cell specific c-type lectin; C-type lectindomain family 4, member K; Langerin; OTTHUMP00000203299; CD207 antigen
• Gene ID: 50489
• mRNA Refseq: NM_015717
• Protein Refseq: NP_056532
• MIM: 604862
• UniProt ID: Q9UJ71
• Chromosome Location: 2p13
• Pathway: Adaptive ImmuneSystem; Antigen processing-Cross presentation; Class I MHC mediated antigenprocessing & presentation; Cross-presentation of soluble exogenousantigens (endosomes); Immune System
• Function: binding; mannosebinding; sugar binding