CD207
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Official Full Name
CD207 molecule, langerin -
Overview
The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity. [provided by RefSeq, Aug 2010] -
Synonyms
CD207;CD207 molecule, langerin;CLEC4K;C-type lectin domain family 4 member K;CD207 antigen, langerin;Langerhans cell specific c-type lectin;C-type lectin domain family 4, member K
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- E.coli
- Mammalian cells
- Wheat Germ
- HEK293
- Insect Cell
- Human Cells
- HEK293T
- In Vitro Cell Free System
- Mamanlian cells
- GST
- His
- Non
- Myc&DDK
- Fc
- Flag
- His&Fc&Avi
- His&GST
Involved Pathway
CD207 involved in several pathways and played different roles in them. We selected most pathways CD207 participated on our site, such as Adaptive Immune System,Antigen processing-Cross presentation,Class I MHC mediated antigen processing &, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD207 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Class I MHC mediated antigen processing & | ASB17,SEC61B,STUB1,ATG7,UBE2L6,SPSB4,PJA1,UFL1,RNF4,ASB7 |
| presentation | ASB14,SH3RF1,LRRC41,TRAF7,KLHL20,FBXO44,RNF34,FBXO27,RNF14,RNF220 |
| Cross-presentation of soluble exogenous antigens (endosomes) | FCGR1B |
| Antigen processing-Cross presentation | CTSL2,CYBB,CTSL1,FCGR1B,SEC61B,CYBA,CTSS |
| Adaptive Immune System | CRTAM,SLAMF6,TREML2,UBE2L6,CHUK,SH3RF1,TRIM9,ASB9,DTX3L,CTLA4 |
| Immune System | CLEC4A,PELI1,CTSLL,MKRN1,ACTR2B,RNF41,WIPF3,HCST,ASB14,TLR6 |
Protein Function
CD207 has several biochemical functions, for example, carbohydrate binding,mannose binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD207 itself. We selected most functions CD207 had, and list some proteins which have the same functions with CD207. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| mannose binding | MAN2B1,CLEC4M,MBL1,DPM1,CLN5,COLEC10,CD209C,LMAN1,CD209A,CD209 |
| carbohydrate binding | LGALS9C,ILLR3,KLRA8,CD72,CLEC7A,GANC,KLRG1,CD248,PVRL1,CD209C |
Interacting Protein
CD207 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD207 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD207.
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Resources
Research Area
Conventional/Classical Dendritic CellsLangerhans and Dermal Dendritic Cells
CD Antigen (Dendritic Cell Pathogen Recognition Uptake)
C-type Lectin Receptors
Dendritic Cell Pathogen Recognition/Uptake
C-type Lectin Family
Related Services
Related Products
References
- Vorobjova, T; Uibo, O; et al. Increased density of tolerogenic dendritic cells in the small bowel mucosa of celiac patients. WORLD JOURNAL OF GASTROENTEROLOGY 21:439-452(2015).
- Stoitzner, P; Schaffenrath, S; et al. Human skin dendritic cells can be targeted in situ by intradermal injection of antibodies against lectin receptors. EXPERIMENTAL DERMATOLOGY 23:909-915(2014).
