Active Recombinant Human CASP4 Protein

• Cat.No.: CASP4-01H
• Product Overview: Recombinant Human CASP4 Protein without tag was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Description: This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms.
• Form: Liquid
• Bio-activity: Activity: 100 U/μL
  Specific Activity: One U=1 pmol/min at 30 centigrade using Ac-LEHD-pNA as substrate.
• Molecular Mass: 19 + 10 kDa
• Purity: >90%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain.
• Storage: At -80 centigrade.
• Storage Buffer: In 50mM HEPES, pH 7.4, 100mM NaCl, 0.5% CHAPS, 1mM EDTA, 10% glycerol, 10mM DTT.
• Shipping: Dry Ice

Gene Information

• Gene Name: CASP4 caspase 4 [ Homo sapiens (human) ]
• Official Symbol: CASP4 caspase 4 [ Homo sapiens (human) ]
• Synonyms: CASP4; caspase 4; TX; Mih1; ICH-2; Mih1/TX; ICEREL-II; ICE(rel)II; caspase-4; CASP-4; ICE and Ced-3 homolog 2; ICE(rel)-II; apoptotic cysteine protease Mih1/TX; caspase 4, apoptosis-related cysteine peptidase; caspase 4, apoptosis-related cysteine protease; protease ICH-2; protease TX; EC 3.4.22.57
• Gene ID: 837
• mRNA Refseq: NM_001225
• Protein Refseq: NP_001216
• MIM: 602664
• UniProt ID: P49662