Active Recombinant Human BMP5 Protein

• Cat.No.: BMP5-014H
• Product Overview: The mature recombinant human BMP-5 protein consists of 148 amino acids (317-454) without tag was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Protein Length: 317-454 a.a.
• Description: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Polymorphisms in this gene may be associated with osteoarthritis in human patients. This gene is differentially regulated in multiple human cancers. This gene encodes distinct protein isoforms that may be similarly proteolytically processed.
• Bio-activity: Measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells. The ED50 for this effect is 0.5-2 μg/mL.
• Molecular Mass: 19 kDa
• Product-Related Proteins: 317-454
• Endotoxin: < 0.1 EU/μg of the protein as determined by the LAL method
• Purity: > 95 % as determined by SDS-PAGE
• Storage: At -80 centigrade. Avoid repeated freeze-thaw cycles.
• Storage Buffer: PBS

Gene Information

• Gene Name: BMP5 bone morphogenetic protein 5 [ Homo sapiens (human) ]
• Official Symbol: BMP5
• Synonyms: BMP5; bone morphogenetic protein 5; bone morphogenetic protein 5
• Gene ID: 653
• mRNA Refseq: NM_021073
• Protein Refseq: NP_066551
• MIM: 112265
• UniProt ID: P22003