Active Recombinant Human ALPL Protein (18-501aa), C-His-tagged
| Cat.No. : | ALPL-01H |
| Product Overview : | Recombinant human Alkaline Phosphatase/ALPL (18-501aa), fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques. |
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| Description : | This gene encodes a member of the alkaline phosphatase family of proteins. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme may play a role in bone mineralization. Mutations in this gene have been linked to hypophosphatasia, a disorder that is characterized by hypercalcemia and skeletal defects. |
| Source : | HEK293 |
| Species : | Human |
| Tag : | His |
| Form : | Liquid |
| Bio-activity : | > 40,000 pmol/min/μg and is defined as the amount of enzyme that hydrolyze 1pmole of 4-Methylumbelliferyl phosphate to phosphate and 4-Methylumbelliferone per minute at pH 8.8 at 37 centigrade. |
| Molecular Mass : | 54.3 kDa (493aa) |
| Protein length : | 18-501aa |
| AA Sequence : | |
| Endotoxin : | < 1 EU/μg of protein (determined by LAL method) |
| Purity : | > 95% by SDS-PAGE |
| Applications : | SDS-PAGE, Enzyme Activity |
| Notes : | For research use only. This product is not intended or approved for human, diagnostics or veterinary use. |
| Storage : | Can be stored at +2 to +8 centigrade for 1 week. For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles. |
| Concentration : | 1 mg/mL (determined by Absorbance at 280nm) |
| Storage Buffer : | Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol |
| Gene Name | ALPL alkaline phosphatase, liver/bone/kidney [ Homo sapiens (human) ] |
| Official Symbol | ALPL |
| Synonyms | ALPL; alkaline phosphatase, liver/bone/kidney; HOPS; alkaline phosphatase, tissue-nonspecific isozyme; TNSALP; glycerophosphatase; tissue-nonspecific ALP; alkaline phosphomonoesterase; liver/bone/kidney-type alkaline phosphatase; alkaline phosphatase liver/bone/kidney isozyme; TNAP; APTNAP; AP-TNAP; FLJ40094; FLJ93059; MGC161443; MGC167935; |
| Gene ID | 249 |
| mRNA Refseq | NM_000478 |
| Protein Refseq | NP_000469 |
| MIM | 171760 |
| UniProt ID | P05186 |
Not For Human Consumption!
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