Active Recombinant Full Length Human FUS Protein, C-Flag-tagged

• Cat.No.: FUS-10HFL
• Product Overview: Recombinant Full Length Human FUS Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Bio-activity: Transmission electron microscopy
  Co-immunoprecipitation
  In vitro kinase assay inhibitor
• Molecular Mass: 53.2 kDa
• AA Sequence: MASNDYTQQATQSYGAYPTQPGQGY SQQSSQPYGQQSYSGYSQSTDTSGY GQSSYSSYGQSQNTGYGTQS TPQGYGSTGGYGSSQSSQSSYGQQS SYPGYGQQPAPSSTSGSYGSSSQSS SYGQPQSGSYSQQPSYGGQQ QSYGQQQSYNPPQGYGQQNQYNSSS GGGGGGGGGGNYGQDQSSMSSGGGS GGGYGNQDQSGGGGSGGYGQ QDRGGRGRGGSGGGGGGGGGGYNRS SGGYEPRGRGGGRGGRGGMGGSDRG GFNKFGGPRDQGSRHDSEQD NSDNNTIFVQGLGENVTIESVADYF KQIGIIKTNKKTGQPMINLYTDRET GKLKGEATVSFDDPPSAKAA IDWFDGKEFSGNPIKVSFATRRADF NRGGGNGRGGRGRGGPMGRGGYGGG GSGGGGRGGFPSGGGGGGGQ QRAGDWKCPNPTCENMNFSWRNECN QCKAPKPDGPGGGPGGSHMGGNYGD DRRGGRGGYDRGGYRGRGGD
  RGGFRGGRGGGDRGGFGPGKMDSRG EHRQDRRERPYTRTRPLEQKLISEE DLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Stem cell - Pluripotency

Gene Information

• Gene Name: FUS FUS RNA binding protein [ Homo sapiens (human) ]
• Official Symbol: FUS
• Synonyms: TLS; ALS6; ETM4; FUS1; POMP75; altFUS; HNRNPP2
• Gene ID: 2521
• mRNA Refseq: NM_004960.4
• Protein Refseq: NP_004951.1
• MIM: 137070
• UniProt ID: P35637