Active Recombinant Equine Interleukin 2

• Cat.No.: IL2-255E
• Product Overview: Recombinant Equine IL-2 was expressed inYeast. MW= 14.9 kDa (129 aa).

Specification

• Species: Equine
• Source: Yeast
• Tag: Non
• Description: Interleukin-2 (IL-2) is an interleukin, a type of cytokine immune system signaling molecule, which is a leukocytotrophic hormone that is instrumental in the body"s natural response to microbial infection and in discriminating between foreign (non-self) and self. IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes, the cells that are responsible for immunity.
• Formulation/ Reconstitution: Lyophilized. Reconstitute with sterile phosphate-buffered saline containing at least 0.1% carrier protein.
• Purification: Ion-exchange chromatography.
• Purity: >95% as visualized by SDS-PAGE analysis.
• Amino Acid Sequence: APTSSSKRET QQQLKQLQMD LKLLLEGVNN NKNPKLSKML TFKINMPKKA TELKHLQCLE EELKPLEEML KNFLSKDIKE LMSNINVTVL GLKGSETRFT CEYDDETGTI VEFLNKWITF CQSIFSTMT.
• Bioactivity: The biological activity of equine IL-2 was measured in a cell proliferation assay using carboxyfluoresein diacetate succinimidyl ester-loaded equine PBMC. The ED50 for this effect is typically 0.5 – 1.0 ng/mL.
• Stability And Storage: Stable for up to twelve months from date of receipt at -20°C. Stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. Avoid repeated freeze/thaw cycles.
• Pathways: Allograft rejection; Autoimmune thyroid disease; Cytokine-cytokine receptor interaction; Graft-versus-host disease; Intestinal immune network for IgA production; Jak-STAT signaling pathway; T cell receptor signaling pathway; Type I diabetes mellitus

Gene Information

• Gene Name: IL2 interleukin 2 [ Equus caballus ]
• Synonyms: interleukin 2; IL-2; IL2; interleukin-2; TCGF; T-cell growth factor
• Gene ID: 100034204
• mRNA Refseq: NM_001085433.1
• Protein Refseq: NP_001078902.1
• UniProt ID: P37997
• Chromosome Location: 2